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Academic Journal

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.

  • Authors : Wheeler EC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.

Subjects: Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/drug therapy ; Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/genetics ; Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/metabolism

  • Source: Science translational medicine [Sci Transl Med] 2024 Jan 03; Vol. 16 (728), pp. eade2774. Date of Electronic Publication: 2024 Jan 03.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.

  • Authors : Jin JC; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.; Chen BY

Subjects: Erythropoiesis*/Erythropoiesis*/Erythropoiesis*/genetics ; Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/genetics; Animals

  • Source: Science advances [Sci Adv] 2023 Dec; Vol. 9 (48), pp. eadi7375. Date of Electronic Publication: 2023 Nov 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells.

  • Authors : Ames K; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

Subjects: Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/metabolism ; Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/metabolism ; Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/pathology

  • Source: Science advances [Sci Adv] 2023 Feb 22; Vol. 9 (8), pp. eade8222. Date of Electronic Publication: 2023 Feb 22.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 -mutated myelodysplasia.

Subjects: Anemia* ; Myelodysplastic Syndromes*; Humans

  • Source: Science translational medicine [Sci Transl Med] 2023 Mar; Vol. 15 (685), pp. eabn5135. Date of Electronic Publication: 2023 Mar 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia.

  • Authors : Karantanos T; Division of Hematological Malignancies, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Hospital, Baltimore, MD, USA.; Teodorescu P

Subjects: Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/genetics ; Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/pathology ; Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/Myelodysplastic Syndromes*/genetics

  • Source: Science advances [Sci Adv] 2022 Feb 18; Vol. 8 (7), pp. eabl8952. Date of Electronic Publication: 2022 Feb 18.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

A variant erythroferrone disrupts iron homeostasis in SF3B1 -mutated myelodysplastic syndrome.

  • Authors : Bondu S; Université de Paris, Paris 75006, France.; Institut Cochin, Département Développement, Reproduction, Cancer, Paris 75014, France.

Subjects: Homeostasis*/Homeostasis*/Homeostasis*/drug effects; Iron/Iron/Iron/*metabolism ; Mutation/Mutation/Mutation/*genetics

  • Source: Science translational medicine [Sci Transl Med] 2019 Jul 10; Vol. 11 (500).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

From MDS/AML to iPSC and back again.

  • Authors : Jonas BA; Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA. Email: .

Subjects: Induced Pluripotent Stem Cells* ; Leukemia, Myeloid, Acute* ; Myelodysplastic Syndromes*

  • Source: Science translational medicine [Sci Transl Med] 2017 Mar 08; Vol. 9 (380).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Loss of the tumor suppressor BAP1 causes myeloid transformation.

  • Authors : Dey A; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.; Seshasayee D

Subjects: Cell Transformation, Neoplastic* ; Genes, Tumor Suppressor*; Leukemia, Myelomonocytic, Chronic/Leukemia, Myelomonocytic, Chronic/Leukemia, Myelomonocytic, Chronic/*genetics

  • Source: Science (New York, N.Y.) [Science] 2012 Sep 21; Vol. 337 (6101), pp. 1541-6. Date of Electronic Publication: 2012 Aug 09.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

CD99 is a therapeutic target on disease stem cells in myeloid malignancies.

  • Authors : Chung SS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Subjects: 12E7 Antigen/12E7 Antigen/12E7 Antigen/*metabolism ; Hematopoietic Stem Cells/Hematopoietic Stem Cells/Hematopoietic Stem Cells/*cytology ; Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/*metabolism

  • Source: Science translational medicine [Sci Transl Med] 2017 Jan 25; Vol. 9 (374).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome.

  • Authors : Yang Z; University of Washington, Seattle, WA 98195, USA.; Keel SB

Subjects: Anemia/Anemia/Anemia/*metabolism ; Anemia, Diamond-Blackfan/Anemia, Diamond-Blackfan/Anemia, Diamond-Blackfan/*metabolism ; Anemia, Macrocytic/Anemia, Macrocytic/Anemia, Macrocytic/*metabolism

  • Source: Science translational medicine [Sci Transl Med] 2016 May 11; Vol. 8 (338), pp. 338ra67.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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  • 1-10 of  136 results for ""MYELODYSPLASTIC syndromes""