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Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome.

• Authors : Consiglieri, Giulia; Tucci, Francesca; De Pellegrin, Maurizio

Subjects: HEMATOPOIETIC stem cells; MUCOPOLYSACCHARIDOSIS I; HEMATOPOIETIC stem cell transplantation

• Source: Science Translational Medicine; 5/1/2024, Vol. 16 Issue 745, p1-10, 10p

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Seeding-competent TDP-43 persists in human patient and mouse muscle.

• Authors : Lynch, Eileen M.; Pittman, Sara; Daw, Jil

Subjects: FLUORESCENCE resonance energy transfer; INCLUSION body myositis; DNA-binding proteins

• Source: Science Translational Medicine; 11/27/2024, Vol. 16 Issue 775, p1-16, 16p

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Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.

• Authors : Sullivan, Jeremy M.; Bagnell, Anna M.; Alevy, Jonathan

Subjects: GAIN-of-function mutations; TRPV cation channels; TRP channels

• Source: Science Translational Medicine; 5/22/2024, Vol. 16 Issue 748, p1-14, 14p

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A mammalian-specific Alex3/Gαq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.

• Authors : Izquierdo-Villalba, Ismael; Mirra, Serena; Manso, Yasmina

Subjects: AMPA receptors; MOLECULAR motor proteins; MITOCHONDRIAL proteins

• Source: Science Signaling; 2/6/2024, Vol. 17 Issue 822, p1-21, 21p

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Hypothalamic control of innate social behaviors.

• Authors : Mei, Long; Osakada, Takuya; Lin, Dayu

• Source: Science; 10/27/2023, Vol. 382 Issue 6669, p399-404, 6p, 4 Diagrams

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Development of a MEK inhibitor, NFX-179, as a chemoprevention agent for squamous cell carcinoma.

• Authors : Sarin, Kavita Y.; Kincaid, John; Sell, Brittney

Subjects: ACTINIC keratosis; SQUAMOUS cell carcinoma; CHEMOPREVENTION

• Source: Science Translational Medicine; 10/11/2023, Vol. 15 Issue 717, p1-10, 10p

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Pathophysiology of Dyt1-Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction.

• Authors : Pocratsky, Amanda M.; Nascimento, Filipe; Özyurt, M. Görkem

Subjects: NEURAL circuitry; DYSTONIA; DORSAL root ganglia

• Source: Science Translational Medicine; 5/3/2023, Vol. 15 Issue 694, p1-13, 13p

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Applied Science & Technology Full Text (H.W. Wilson)

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Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries.

• Authors : Wang, Tao; Wagner, Andrea; Gehwolf, Renate

Subjects: LIGAMENT injuries; TENDONS; TENDON injuries

• Source: Science Translational Medicine; 2/24/2021, Vol. 13 Issue 582, p1-13, 13p

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T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.

• Authors : Desdín-Micó, Gabriela; Soto-Heredero, Gonzalo; Aranda, Juan Francisco

• Source: Science; 6/19/2020, Vol. 368 Issue 6497, p1371-1376, 6p, 4 Graphs

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