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Academic Journal

Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy.

  • Authors : Zoler E; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.; Meyer T

Subjects: Receptor, Interferon alpha-beta*/Receptor, Interferon alpha-beta*/Receptor, Interferon alpha-beta*/metabolism ; Receptor, Interferon alpha-beta*/Receptor, Interferon alpha-beta*/Receptor, Interferon alpha-beta*/genetics ; Signal Transduction*

  • Source: Science signaling [Sci Signal] 2024 Nov 19; Vol. 17 (863), pp. eadl1892. Date of Electronic Publication: 2024 Nov 19.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients.

  • Authors : Mathew D; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/immunology ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/therapy

  • Source: Science (New York, N.Y.) [Science] 2024 Jun 21; Vol. 384 (6702), pp. eadf1329. Date of Electronic Publication: 2024 Jun 21.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.

  • Authors : Glassman CR; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Tsutsumi N

Subjects: Janus Kinase 1*/Janus Kinase 1*/Janus Kinase 1*/chemistry ; Janus Kinase 1*/Janus Kinase 1*/Janus Kinase 1*/metabolism ; Receptors, Cytokine*/Receptors, Cytokine*/Receptors, Cytokine*/chemistry

  • Source: Science (New York, N.Y.) [Science] 2022 Apr 08; Vol. 376 (6589), pp. 163-169. Date of Electronic Publication: 2022 Mar 10.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.

  • Authors : Dengler HS; Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.; Wu X

Subjects: Asthma/Asthma/Asthma/*drug therapy ; Asthma/Asthma/Asthma/*enzymology ; Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*antagonists & inhibitors

  • Source: Science translational medicine [Sci Transl Med] 2018 Nov 21; Vol. 10 (468).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

  • Authors : Rutherford C; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.; Speirs C

Subjects: AMP-Activated Protein Kinases/AMP-Activated Protein Kinases/AMP-Activated Protein Kinases/*metabolism ; Endothelial Cells/Endothelial Cells/Endothelial Cells/*metabolism ; Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*metabolism

  • Source: Science signaling [Sci Signal] 2016 Nov 08; Vol. 9 (453), pp. ra109. Date of Electronic Publication: 2016 Nov 08.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.

  • Authors : Katz G; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.; Pobezinsky LA

Subjects: Gene Expression Regulation/Gene Expression Regulation/Gene Expression Regulation/*immunology ; Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*genetics ; MicroRNAs/MicroRNAs/MicroRNAs/*metabolism

  • Source: Science signaling [Sci Signal] 2014 Aug 26; Vol. 7 (340), pp. ra83. Date of Electronic Publication: 2014 Aug 26.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.

  • Authors : Yan B; Department of Biochemistry, Purdue University, West Lafayette, IN, USA.; Freiwald T

Subjects: Complement Activation* ; MAP Kinase Signaling System*; COVID-19/COVID-19/COVID-19/*metabolism

  • Source: Science immunology [Sci Immunol] 2021 Apr 07; Vol. 6 (58).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication

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Academic Journal

MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.

  • Authors : Ahmad R; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Rajabi H

Subjects: Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*metabolism ; Mucin-1/Mucin-1/Mucin-1/*metabolism ; STAT3 Transcription Factor/STAT3 Transcription Factor/STAT3 Transcription Factor/*metabolism

  • Source: Science signaling [Sci Signal] 2011 Feb 15; Vol. 4 (160), pp. ra9. Date of Electronic Publication: 2011 Feb 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

JAKing up immunity.

  • Authors : Gadina M; Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.; O'Shea JJ

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/immunology ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Janus Kinases*/Janus Kinases*/Janus Kinases*/metabolism

  • Source: Science (New York, N.Y.) [Science] 2024 Jun 21; Vol. 384 (6702), pp. 1303-1304. Date of Electronic Publication: 2024 Jun 20.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.

  • Authors : Abraham BG; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Haikarainen T

Subjects: Erythropoietin*/Erythropoietin*/Erythropoietin*/genetics ; Janus Kinase 2*/Janus Kinase 2*/Janus Kinase 2*/genetics ; Janus Kinase 2*/Janus Kinase 2*/Janus Kinase 2*/metabolism

  • Source: Science advances [Sci Adv] 2024 Mar 08; Vol. 10 (10), pp. eadl2097. Date of Electronic Publication: 2024 Mar 08.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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  • 1-10 of  135 results for ""Janus Kinase 1""