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Academic Journal

Programming tissue-sensing T cells that deliver therapies to the brain.

  • Authors : Simic MS; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Watchmaker PB

Subjects: Brain*/Brain*/Brain*/immunology ; Brain Diseases*/Brain Diseases*/Brain Diseases*/therapy ; Cell Engineering*/Cell Engineering*/Cell Engineering*/methods

  • Source: Science (New York, N.Y.) [Science] 2024 Dec 06; Vol. 386 (6726), pp. eadl4237. Date of Electronic Publication: 2024 Dec 06.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.

  • Authors : Bido S; Stem Cell and Neurogenesis Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Nannoni M

Subjects: Interleukin-10*/Interleukin-10*/Interleukin-10*/metabolism ; Interleukin-10*/Interleukin-10*/Interleukin-10*/genetics ; Microglia*/Microglia*/Microglia*/metabolism

  • Source: Science translational medicine [Sci Transl Med] 2024 Aug 21; Vol. 16 (761), pp. eadm8563. Date of Electronic Publication: 2024 Aug 21.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

When a double negative is not a positive: Autoantibodies against IL-10 in patients with inflammatory bowel disease.

  • Authors : Noviello CM; Department of Neurobiology, University of California at San Diego, La Jolla, CA, USA.

Subjects: Autoantibodies*/Autoantibodies*/Autoantibodies*/immunology ; Inflammatory Bowel Diseases*/Inflammatory Bowel Diseases*/Inflammatory Bowel Diseases*/immunology ; Interleukin-10*/Interleukin-10*/Interleukin-10*/immunology

  • Source: Science immunology [Sci Immunol] 2024 Sep 06; Vol. 9 (99), pp. eads7642. Date of Electronic Publication: 2024 Sep 06.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication

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Academic Journal

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice.

  • Authors : Desai P; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.; Karl CE

Subjects: COVID-19*/COVID-19*/COVID-19*/immunology ; COVID-19*/COVID-19*/COVID-19*/prevention & control ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/immunology SARS-CoV-2 variants

  • Source: Science translational medicine [Sci Transl Med] 2024 Aug 21; Vol. 16 (761), pp. eado1941. Date of Electronic Publication: 2024 Aug 21.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.

  • Authors : Saxton RA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Subjects: Interleukin-10/Interleukin-10/Interleukin-10/*chemistry ; Interleukin-10/Interleukin-10/Interleukin-10/*metabolism; Animals

  • Source: Science (New York, N.Y.) [Science] 2021 Mar 19; Vol. 371 (6535).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

RNA binding protein DDX5 restricts RORγt + T reg suppressor function to promote intestine inflammation.

  • Authors : Ma S; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Yang Q

Subjects: Interleukin-10*/Interleukin-10*/Interleukin-10*/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3*/Nuclear Receptor Subfamily 1, Group F, Member 3*/Nuclear Receptor Subfamily 1, Group F, Member 3*/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3*/Nuclear Receptor Subfamily 1, Group F, Member 3*/Nuclear Receptor Subfamily 1, Group F, Member 3*/metabolism

  • Source: Science advances [Sci Adv] 2023 Feb 03; Vol. 9 (5), pp. eadd6165. Date of Electronic Publication: 2023 Feb 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Interleukin-10 from CD4 + follicular regulatory T cells promotes the germinal center response.

  • Authors : Laidlaw BJ; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Lu Y

Subjects: Arenaviridae Infections/Arenaviridae Infections/Arenaviridae Infections/*immunology ; B-Lymphocytes/B-Lymphocytes/B-Lymphocytes/*immunology ; Germinal Center/Germinal Center/Germinal Center/*immunology

  • Source: Science immunology [Sci Immunol] 2017 Oct 20; Vol. 2 (16).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication

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Academic Journal

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.

  • Authors : Gorby C; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK.; Sotolongo Bellón J

Subjects: CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*immunology ; Interleukin-10/Interleukin-10/Interleukin-10/*immunology ; Monocytes/Monocytes/Monocytes/*immunology

  • Source: Science signaling [Sci Signal] 2020 Sep 15; Vol. 13 (649). Date of Electronic Publication: 2020 Sep 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production.

  • Authors : Na YR; Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, 103 Daehak-ro, Chongno-gu, Seoul 110-799, South Korea.; Jung D

Subjects: Cyclin-Dependent Kinase 5/Cyclin-Dependent Kinase 5/Cyclin-Dependent Kinase 5/*metabolism ; Interleukin-10/Interleukin-10/Interleukin-10/*biosynthesis ; Lipopolysaccharides/Lipopolysaccharides/Lipopolysaccharides/*pharmacology

  • Source: Science signaling [Sci Signal] 2015 Nov 24; Vol. 8 (404), pp. ra121. Date of Electronic Publication: 2015 Nov 24.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

  • Authors : Steidler L; Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium. ; Hans W

Subjects: Inflammatory Bowel Diseases/Inflammatory Bowel Diseases/Inflammatory Bowel Diseases/*therapy ; Interleukin-10/Interleukin-10/Interleukin-10/*administration & dosage ; Interleukin-10/Interleukin-10/Interleukin-10/*biosynthesis

  • Source: Science (New York, N.Y.) [Science] 2000 Aug 25; Vol. 289 (5483), pp. 1352-5.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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