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Academic Journal

DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity.

  • Authors : Kureshi R; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.

Subjects: Diglycerides*/Diglycerides*/Diglycerides*/metabolism ; Neoplasms*; Mice

  • Source: Science advances [Sci Adv] 2023 Nov 24; Vol. 9 (47), pp. eadk1853. Date of Electronic Publication: 2023 Nov 24.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse.

  • Authors : Stinchcombe JC; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.; Asano Y

Subjects: Receptors, Antigen, T-Cell*/Receptors, Antigen, T-Cell*/Receptors, Antigen, T-Cell*/metabolism ; T-Lymphocytes, Cytotoxic*/T-Lymphocytes, Cytotoxic*/T-Lymphocytes, Cytotoxic*/immunology ; Exocytosis*/Exocytosis*/Exocytosis*/immunology

  • Source: Science (New York, N.Y.) [Science] 2023 May 26; Vol. 380 (6647), pp. 818-823. Date of Electronic Publication: 2023 May 25.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.

  • Authors : Pilo CA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA.

Subjects: Diglycerides*/Diglycerides*/Diglycerides*/metabolism ; Spinocerebellar Ataxias*/Spinocerebellar Ataxias*/Spinocerebellar Ataxias*/genetics; Animals Spinocerebellar ataxia 14

  • Source: Science signaling [Sci Signal] 2022 Sep 27; Vol. 15 (753), pp. eabk1147. Date of Electronic Publication: 2022 Sep 27.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity.

  • Authors : Cooke M; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA 19141, USA.

Subjects: Diglycerides*/Diglycerides*/Diglycerides*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/therapy; Animals

  • Source: Science signaling [Sci Signal] 2022 Apr 12; Vol. 15 (729), pp. eabo0264. Date of Electronic Publication: 2022 Apr 12.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

New connections: NHERF gates activity.

  • Authors : Gough NR; Science Signaling, AAAS, Washington, DC 20005, USA.

Subjects: Diglycerides* ; Sodium-Hydrogen Exchangers*; Phosphoproteins

  • Source: Science signaling [Sci Signal] 2017 Jan 10; Vol. 10 (461). Date of Electronic Publication: 2017 Jan 10.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells.

  • Authors : Andrada E; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB-CSIC), E-28049 Madrid, Spain.; Almena M

Subjects: Diacylglycerol Kinase/Diacylglycerol Kinase/Diacylglycerol Kinase/*immunology ; Diglycerides/Diglycerides/Diglycerides/*immunology ; Immunological Synapses/Immunological Synapses/Immunological Synapses/*immunology

  • Source: Science signaling [Sci Signal] 2016 Dec 20; Vol. 9 (459), pp. ra127. Date of Electronic Publication: 2016 Dec 20.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.

  • Authors : de Rubio RG; Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.; Ransom RF

Subjects: Diglycerides/Diglycerides/Diglycerides/*metabolism ; Phosphatidylinositol Phosphates/Phosphatidylinositol Phosphates/Phosphatidylinositol Phosphates/*metabolism ; Phosphatidylinositols/Phosphatidylinositols/Phosphatidylinositols/*metabolism

  • Source: Science signaling [Sci Signal] 2018 Sep 11; Vol. 11 (547). Date of Electronic Publication: 2018 Sep 11.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane.

  • Authors : Baron CL; Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA.; Malhotra V

Subjects: Fumonisins* ; Membrane Glycoproteins* ; Protein Transport*

  • Source: Science (New York, N.Y.) [Science] 2002 Jan 11; Vol. 295 (5553), pp. 325-8. Date of Electronic Publication: 2001 Nov 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions.

  • Authors : Mérida I; Department of Immunology and Oncology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, E-28049 Madrid, Spain. .; Andrada E

Subjects: Tumor Escape*; Autoimmune Diseases/Autoimmune Diseases/Autoimmune Diseases/*immunology ; Diacylglycerol Kinase/Diacylglycerol Kinase/Diacylglycerol Kinase/*immunology

  • Source: Science signaling [Sci Signal] 2015 Apr 28; Vol. 8 (374), pp. re6. Date of Electronic Publication: 2015 Apr 28.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

  • Authors : Chauveau A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Le Floc'h A

Subjects: CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/*cytology ; Cell Polarity/Cell Polarity/Cell Polarity/*immunology ; Diacylglycerol Kinase/Diacylglycerol Kinase/Diacylglycerol Kinase/*metabolism

  • Source: Science signaling [Sci Signal] 2014 Aug 26; Vol. 7 (340), pp. ra82. Date of Electronic Publication: 2014 Aug 26.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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