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Does the binding of cyclosporine to calmodulin result in immunosuppression?

• Authors : LeGrue SJ; Turner R; Weisbrodt N

Subjects: Cyclosporine*; Calmodulin/Calmodulin/Calmodulin/*physiology ; Cyclosporins/Cyclosporins/Cyclosporins/*pharmacology

• Source: Science (New York, N.Y.) [Science] 1986 Oct 03; Vol. 234 (4772), pp. 68-71.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Signaling path may lead to better heart-failure therapies.

• Authors : Barinaga M

Subjects: Calcineurin Inhibitors* ; Nuclear Proteins*; Cyclosporine/Cyclosporine/Cyclosporine/*pharmacology

• Source: Science (New York, N.Y.) [Science] 1998 Apr 17; Vol. 280 (5362), pp. 383.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex.

• Authors : Altschuh D; Vix O; Rees B

Subjects: Cyclosporine/Cyclosporine/Cyclosporine/*chemistry ; Immunoglobulin Fab Fragments/Immunoglobulin Fab Fragments/Immunoglobulin Fab Fragments/*chemistry; Amino Acid Isomerases/Amino Acid Isomerases/Amino Acid Isomerases/chemistry

• Source: Science (New York, N.Y.) [Science] 1992 Apr 03; Vol. 256 (5053), pp. 92-4.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Receptor-induced conformation change of the immunosuppressant cyclosporin A.

• Authors : Wüthrich K; Institut für Molekularbiologie und Biophysik, Eidgenössische Technische Hochschule-Hönggerberg, Zürich, Switzerland.; von Freyberg B

Subjects: Cyclosporine*/Cyclosporine*/Cyclosporine*/chemistry; Amino Acid Isomerases/Amino Acid Isomerases/Amino Acid Isomerases/*ultrastructure ; Carrier Proteins/Carrier Proteins/Carrier Proteins/*ultrastructure

• Source: Science (New York, N.Y.) [Science] 1991 Nov 15; Vol. 254 (5034), pp. 953-4.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Rusting of the lock and key model for protein-ligand binding.

• Authors : Jorgensen WL; Department of Chemistry, Yale University, New Haven, CT 06511.

Subjects: Cyclosporine*/Cyclosporine*/Cyclosporine*/chemistry ; Tacrolimus*/Tacrolimus*/Tacrolimus*/chemistry; Amino Acid Isomerases/Amino Acid Isomerases/Amino Acid Isomerases/metabolism

• Source: Science (New York, N.Y.) [Science] 1991 Nov 15; Vol. 254 (5034), pp. 954-5.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.

• Authors : Miyata H; Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.; Satouh Y

Subjects: Calcineurin/Calcineurin/Calcineurin/*physiology ; Calcineurin Inhibitors/Calcineurin Inhibitors/Calcineurin Inhibitors/*pharmacology ; Contraceptive Agents, Male/Contraceptive Agents, Male/Contraceptive Agents, Male/*pharmacology

• Source: Science (New York, N.Y.) [Science] 2015 Oct 23; Vol. 350 (6259), pp. 442-5. Date of Electronic Publication: 2015 Oct 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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DEVELOPMENTAL BIOLOGY. Toward a rapid and reversible male pill.

• Authors : Castaneda J; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.; Matzuk MM

Subjects: Calcineurin/Calcineurin/Calcineurin/*physiology ; Calcineurin Inhibitors/Calcineurin Inhibitors/Calcineurin Inhibitors/*pharmacology ; Contraceptive Agents, Male/Contraceptive Agents, Male/Contraceptive Agents, Male/*pharmacology

• Source: Science (New York, N.Y.) [Science] 2015 Oct 23; Vol. 350 (6259), pp. 385-6. Date of Electronic Publication: 2015 Oct 22.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Education Full Text (H.W. Wilson)

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Education Full Text (H.W. Wilson)

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Prevention of cardiac hypertrophy in mice by calcineurin inhibition.

• Authors : Sussman MA; Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.; Lim HW

Subjects: Calcineurin Inhibitors* ; Cardiac Myosins* ; Microfilament Proteins*

• Source: Science (New York, N.Y.) [Science] 1998 Sep 11; Vol. 281 (5383), pp. 1690-3.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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