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Publisher : american association for the advancement of science

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Academic Journal

BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.

Authors : Judd AS; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA.; Bawa B

Subjects: bcl-X Protein*/bcl-X Protein*/bcl-X Protein*/antagonists & inhibitors ; bcl-X Protein*/bcl-X Protein*/bcl-X Protein*/metabolism ; Immunoconjugates*/Immunoconjugates*/Immunoconjugates*/pharmacology

Source: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eado7120. Date of Electronic Publication: 2024 Oct 04.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.

Authors : Judd, Andrew S.¹; Bawa, Bhupinder¹; Buck, Wayne R.¹

Subjects: *ANTIBODY-drug conjugates; *EPIDERMAL growth factor; *CARDIOTOXICITY

Source: Science Advances. 10/4/2024, Vol. 10 Issue 40, p1-18. 18p.

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Academic Journal

Intraoperative evaluation of tumor margins using a TROP2 near-infrared imaging probe to enable human breast-conserving surgery.

Authors : Chen, Weiling; Zhang, Yongqu; Zhang, Lixin

Subjects: CELL surface antigens; SURGICAL margin; BREAST tumors

Source: Science Translational Medicine; 10/16/2024, Vol. 16 Issue 769, p1-14, 14p

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Academic Journal

An anti–TNF–glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases.

Authors : McPherson, Michael J.; Hobson, Adrian D.; Hernandez Jr., Axel

Subjects: ANTIBODY-drug conjugates; THERAPEUTICS; CONTACT dermatitis

Source: Science Translational Medicine; 3/20/2024, Vol. 16 Issue 739, p1-12, 12p

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Academic Journal

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases.

Authors : Dai Z; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.; Zhang XN

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/therapeutic use ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/metabolism

Source: Science advances [Sci Adv] 2020 Jun 03; Vol. 6 (23), pp. eaba6752. Date of Electronic Publication: 2020 Jun 03 (Print Publication: 2020).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases.

Authors : Zhefu Dai¹; Xiao-Nan Zhang¹; Fariborz Nasertorabi²

Subjects: *ANTIBODY-drug conjugates; *CD38 antigen; *LIFE sciences

Source: Science Advances. 6/3/2020, Vol. 6 Issue 23, p1-12. 12p.

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Academic Journal

Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer.

Authors : Yamada, Yasutaka; Venkadakrishnan, Varadha Balaji; Mizuno, Kei

Subjects: DECITABINE; PROSTATE cancer; DNA methylation

Source: Science Translational Medicine; 11/15/2023, Vol. 15 Issue 722, p1-17, 17p

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Academic Journal

An "Ama"-zing antibody-drug conjugate.

Authors : C. S. M.

Subjects: *ANTIBODY-drug conjugates

Source: Science Advances. 2/10/2021, Vol. 7 Issue 7, p688-688. 1/6p.

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Academic Journal

Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate.

Authors : Kong, Fan-En; Li, Guang-Meng; Tang, Yun-Qiang

Subjects: ANTIBODY-drug conjugates; HEPATOCELLULAR carcinoma; EMBRYONIC stem cells

Source: Science Translational Medicine; 2/3/2021, Vol. 13 Issue 579, p1-16, 16p

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Academic Journal

Aiming the magic bullet.

Authors : Baca, Justin T.

Subjects: ANTIBODY-drug conjugates; BULLETS; CO-sleeping

Source: Science Translational Medicine; 11/18/2020, Vol. 12 Issue 570, pN.PAG-N.PAG, 1p

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