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Academic Journal

Bacterial expression, purification, and characterization of human cytochrome P450 3A4 without N-terminal modifications.

Subjects: *CYTOCHROME P-450 CYP3A; *ESCHERICHIA coli; *CYTOCHROME P-450

  • Source: Archives of Biochemistry & Biophysics. Dec2024, Vol. 762, pN.PAG-N.PAG. 1p.

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Co-based carbon material as CYP3A4-like nanozyme with both biocatalytic activity and inhibition behaviors.

Subjects: *CYTOCHROME P-450 CYP3A; *CARBON-based materials; *DRUG metabolism

  • Source: Bioorganic Chemistry. Dec2024, Vol. 153, pN.PAG-N.PAG. 1p.

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Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and comparison with ritonavir.

Subjects: *RITONAVIR; *CYTOCHROME P-450 CYP3A; *CYTOCHROME c

  • Source: Archives of Biochemistry & Biophysics. Aug2024, Vol. 758, pN.PAG-N.PAG. 1p.

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5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells.

Subjects: *CYTOCHROME P-450 CYP3A; *HEME; *CYTOCHROME P-450

  • Source: Biochemical & Biophysical Research Communications. Jul2023, Vol. 664, p94-99. 6p.

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Molecular docking and in vitro evaluations reveal the role of human cytochrome P450 3A4 in the cross-coupling metabolism of phenolic xenobiotics.

Subjects: Cytochrome P-450 CYP3A; Xenobiotics; Molecular docking

  • Source: Environmental Research. Mar2023, Vol. 220, pN.PAG-N.PAG. 1p.

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Tissue re-distribution of budesonide in rats co-administrated with curcumin by ultra performance liquid chromatography-tandem mass spectrometry.

Subjects: *LIQUID chromatography-mass spectrometry; *CYTOCHROME P-450 CYP3A; *CURCUMIN

  • Source: Analytical Biochemistry. Oct2023, Vol. 679, pN.PAG-N.PAG. 1p.

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Academic Journal

Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism.

Subjects: *CYTOCHROME P-450 CYP2C19; *CYTOCHROME P-450 CYP3A; *GENETIC polymorphisms

  • Source: Toxicology & Applied Pharmacology. Sep2023, Vol. 475, pN.PAG-N.PAG. 1p.

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Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles.

Subjects: *CYTOCHROME P-450 CYP2C19; *CYTOCHROME P-450 CYP3A; *VORICONAZOLE

  • Source: Toxicology & Applied Pharmacology. May2023, Vol. 466, pN.PAG-N.PAG. 1p.

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Low molecular weight ligands bind to CYP3A4 via a branched induced fit mechanism: Implications for O2 binding.

Subjects: *MOLECULAR weights; *CYTOCHROME P-450 CYP3A; *LIGANDS (Biochemistry)

  • Source: Archives of Biochemistry & Biophysics. May2023, Vol. 739, pN.PAG-N.PAG. 1p.

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Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions.

Subjects: *CYTOCHROME P-450 CYP3A; *LIVER microsomes; *ENZYME kinetics

  • Source: Toxicology & Applied Pharmacology. Jun2022, Vol. 445, pN.PAG-N.PAG. 1p.

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  • 1-10 of  26 results for ""Cytochrome P-450 CYP3A""