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Academic Journal

The impact of CYP3A4 genetic polymorphism on crizotinib metabolism and drug-drug interactions.

  • Authors : Wang J; Institute of Molecular Toxicology and Pharmacology, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.; Xu XY

Subjects: Crizotinib*/Crizotinib*/Crizotinib*/pharmacokinetics ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/genetics ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Aug; Vol. 489, pp. 117016. Date of Electronic Publication: 2024 Jun 24.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

Pharmacogenomic predictor of long-term residual chemotherapy-induced peripheral neuropathy in ovarian cancer survivors: A substudy of the GINECO Vivrovaire study.

  • Authors : Zenatri M; Department of Medical Oncology, Institut de Cancerologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France.; Perennec T

Subjects: Peripheral Nervous System Diseases*/Peripheral Nervous System Diseases*/Peripheral Nervous System Diseases*/chemically induced ; Peripheral Nervous System Diseases*/Peripheral Nervous System Diseases*/Peripheral Nervous System Diseases*/genetics ; Polymorphism, Single Nucleotide*

  • Source: Gynecologic oncology [Gynecol Oncol] 2024 Aug; Vol. 187, pp. 139-144. Date of Electronic Publication: 2024 May 21.Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited

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Academic Journal

The effect of shikonin on the metabolism of lapatinib in vitro, and in vivo.

  • Authors : Hu Y; The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.; Xie S

Subjects: Tandem Mass Spectrometry*/Tandem Mass Spectrometry*/Tandem Mass Spectrometry*/methods ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Naphthoquinones*

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Jan; Vol. 482, pp. 116797. Date of Electronic Publication: 2023 Dec 30.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism.

  • Authors : Yuan LJ; Department of Pharmacy, Shaoxing Second Hospital, Shaoxing, Zhejiang, China.; Li XY

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/genetics ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Ibuprofen*

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Sep 15; Vol. 475, pp. 116653. Date of Electronic Publication: 2023 Aug 14.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles.

  • Authors : Gong F; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China; Center for Molecular Diagnosis and Precision Medicine, Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Subjects: Tacrolimus* ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/genetics; Humans

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 May 01; Vol. 466, pp. 116475. Date of Electronic Publication: 2023 Mar 16.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

High-throughput cytochrome P450 loss and metabolic intermediate complex assays to aid in designing out of CYP3A inactivation.

  • Authors : Russell DA; Department of Medicinal Chemistry, University of Washington, Seattle, WA, United States.; Cerny MA

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/pharmacology ; Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/Cytochrome P-450 Enzyme Inhibitors*/metabolism

  • Source: Methods in enzymology [Methods Enzymol] 2023; Vol. 690, pp. 341-368. Date of Electronic Publication: 2023 Sep 09.Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited

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Academic Journal

Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions.

  • Authors : Li X; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Subjects: Aconitine*/Aconitine*/Aconitine*/analogs & derivatives ; Aconitine*/Aconitine*/Aconitine*/pharmacology ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jun 15; Vol. 445, pp. 116024. Date of Electronic Publication: 2022 Apr 16.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology.

  • Authors : Leow JWH; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.; Tang LWT

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism; Humans

  • Source: Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2022; Vol. 95, pp. 131-176. Date of Electronic Publication: 2022 Jun 30.Publisher: Academic Press Country of Publication: United States NLM ID: 9015397 Publication Model: Print-Electronic Cited

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Academic Journal

CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.

  • Authors : Qin X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China; Center of Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States.

Subjects: Bile Acids and Salts/Bile Acids and Salts/Bile Acids and Salts/*blood ; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*deficiency ; Intestine, Small/Intestine, Small/Intestine, Small/*enzymology

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Oct 15; Vol. 429, pp. 115703. Date of Electronic Publication: 2021 Aug 28.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

Effect of CYP3A4*22 and CYP3A4*1B but not CYP3A5*3 polymorphisms on tacrolimus pharmacokinetic model in Tunisian kidney transplant.

  • Authors : Hannachi I; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia; Faculty of Sciences of Bizerte, Carthage University, Tunisia. Electronic address: .

Subjects: Kidney Transplantation*; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*genetics ; Immunosuppressive Agents/Immunosuppressive Agents/Immunosuppressive Agents/*pharmacokinetics

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Jun 01; Vol. 396, pp. 115000. Date of Electronic Publication: 2020 Apr 07.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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  • 1-10 of  106 results for ""Cytochrome P-450 CYP3A""