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Academic Journal

STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells.

  • Authors : Li CL; Department of Neurology, The First Affiliated Hospital Of Chongqing Medical University, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, 1 Youyi Road, Chongqing 400016, China.; Zhou GF

Subjects: tau Proteins*/tau Proteins*/tau Proteins*/metabolism ; tau Proteins*/tau Proteins*/tau Proteins*/genetics ; RNA-Binding Proteins*/RNA-Binding Proteins*/RNA-Binding Proteins*/metabolism

  • Source: Experimental neurology [Exp Neurol] 2024 Jul; Vol. 377, pp. 114805. Date of Electronic Publication: 2024 May 08.Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited

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Academic Journal

Cell-free protein production of a gamma secretase homolog.

  • Authors : Moser C; Institute for Biological Interfaces 4, Karlsruhe Institute of Technology, 76344 Eggenstein- Leopoldshafen, Germany; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/genetics ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: Protein expression and purification [Protein Expr Purif] 2024 Mar; Vol. 215, pp. 106407. Date of Electronic Publication: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited

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Academic Journal

Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair.

  • Authors : Revol RS; Stockholm University, Department of Biochemistry and Biophysics, 106 91 Stockholm, Sweden.; Koistinen NA

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/metabolism; Nuclear Proteins/Nuclear Proteins/Nuclear Proteins/metabolism

  • Source: Molecular and cellular neurosciences [Mol Cell Neurosci] 2023 Dec; Vol. 127, pp. 103903. Date of Electronic Publication: 2023 Nov 02.Publisher: Academic Press Country of Publication: United States NLM ID: 9100095 Publication Model: Print-Electronic Cited

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Academic Journal

Gamma secretase inhibition: Effects on fertility and embryo-fetal development in rats.

  • Authors : Sivaraman L; Nonclinical Safety, Bristol-Myers Squibb, New Brunswick, NJ, USA. Electronic address: .; Sanderson T

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/therapeutic use ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy

  • Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Jun 15; Vol. 469, pp. 116512. Date of Electronic Publication: 2023 Apr 06.Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited

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Academic Journal

Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.

  • Authors : Janssens J; Department of Neuroscience, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.; Hermans B

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*antagonists & inhibitors ; Antibodies, Monoclonal/Antibodies, Monoclonal/Antibodies, Monoclonal/*administration & dosage

  • Source: Neurobiology of disease [Neurobiol Dis] 2021 Jul; Vol. 154, pp. 105365. Date of Electronic Publication: 2021 Apr 10.Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited

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Academic Journal

Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.

  • Authors : Saadipour K; Departments of Cell Biology, Physiology & Neuroscience, and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, New York 10016, USA. Electronic address: .; Tiberi A

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism ; Brain Injuries, Traumatic/Brain Injuries, Traumatic/Brain Injuries, Traumatic/*metabolism

  • Source: Molecular and cellular neurosciences [Mol Cell Neurosci] 2019 Sep; Vol. 99, pp. 103395. Date of Electronic Publication: 2019 Aug 15.Publisher: Academic Press Country of Publication: United States NLM ID: 9100095 Publication Model: Print-Electronic Cited

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Academic Journal

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

  • Authors : Lu MH; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho- Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

Subjects: Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/genetics ; Presenilin-1*/Presenilin-1*/Presenilin-1*/genetics; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism

  • Source: Experimental neurology [Exp Neurol] 2019 Jan; Vol. 311, pp. 67-79. Date of Electronic Publication: 2018 Sep 20.Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited

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Academic Journal

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.

  • Authors : Llufriu-Dabén G; INSERM UMR-S 1124, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France.; Carrete A

Subjects: Remyelination*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism

  • Source: Neurobiology of disease [Neurobiol Dis] 2018 Jan; Vol. 109 (Pt A), pp. 11-24. Date of Electronic Publication: 2017 Sep 18.Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited

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Academic Journal

Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins.

  • Authors : Veugelen S; University of Leuven, Leuven, Belgium; VIB Center for Brain and Disease, Leuven, Belgium.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*enzymology ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry ; Molecular Biology/Molecular Biology/Molecular Biology/*methods

  • Source: Methods in enzymology [Methods Enzymol] 2017; Vol. 584, pp. 59-97. Date of Electronic Publication: 2016 Dec 12.Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited

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Academic Journal

Enzymatic Assays for Studying Intramembrane Proteolysis.

  • Authors : Bolduc DM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Selkoe DJ

Subjects: Proteolysis*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*enzymology ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry

  • Source: Methods in enzymology [Methods Enzymol] 2017; Vol. 584, pp. 295-308. Date of Electronic Publication: 2016 Dec 24.Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited

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  • 1-10 of  181 results for ""Amyloid Precursor Protein Secretases""