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The First In Vivo Study Shows That Gyrophoric Acid Changes Behavior of Healthy Laboratory Rats.

• Authors : Simko, Patrik; Leskanicova, Andrea; Suvakova-Nunhart, Maria

Subjects: LABORATORY rats; LIVER microsomes; SPRAGUE Dawley ratsCZECH Republic

• Source: International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 12, p6782, 21p

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A Physiologically Based Pharmacokinetic Model to Predict Determinants of Variability in Epirubicin Exposure and Tissue Distribution.

• Authors : Ansaar, Radwan; Meech, Robyn; Rowland, Andrew

Subjects: EPIRUBICIN; BREAST; SERUM albuminPRINCETON University

• Source: Pharmaceutics; Apr2023, Vol. 15 Issue 4, p1222, 15p

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Agricola

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Agricola

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The comparative interaction of human and bovine serum albumins with CYP2C9 in human liver microsomes.

• Authors : Zhou Q; Department of Pharmacology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto M5S 1A8, Canada.; Matsumoto S

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*metabolism ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*enzymology ; Serum Albumin/Serum Albumin/Serum Albumin/*pharmacology

• Source: Life sciences [Life Sci] 2004 Sep 17; Vol. 75 (18), pp. 2145-55.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print Cited Medium: Print ISSN: 0024-3205 (Print)

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Pharmacokinetic interference of doxorubicin with tolbutamide due to reduced metabolic clearance with increased serum unbound fraction in rats.

• Authors : Fukuno, Shuhei; Nagai, Katsuhito; Yamamoto, Kohei

Subjects: TOLBUTAMIDE; SERUM albumin; RATS

• Source: Biopharmaceutics & Drug Disposition; Jul2019, Vol. 40 Issue 7, p225-233, 9p

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Agricola

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The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities.

• Authors : Rowland A; Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia.; Knights KM

Subjects: Glucuronosyltransferase/Glucuronosyltransferase/Glucuronosyltransferase/*metabolism ; Hymecromone/Hymecromone/Hymecromone/*analogs & derivatives ; Propofol/Propofol/Propofol/*metabolism

• Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2008 Jun; Vol. 36 (6), pp. 1056-62. Date of Electronic Publication: 2008 Mar 24.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation.

• Authors : Amer, Sawsan; Kadi, Adnan; Darwish, Hany

Subjects: LIQUID chromatography-mass spectrometry; PROTEIN-tyrosine kinase inhibitors; VASCULAR endothelial growth factors

• Source: Chemistry Central Journal; 5/30/2017, Vol. 11 Issue 1, p1-8, 8p

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Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability.

• Authors : Kadi, Adnan A.; Darwish, Hany W.; Attwa, Mohamed W.

Subjects: PROTEIN-tyrosine kinase inhibitors; LIVER microsomes; BLOOD plasma

• Source: PLoS ONE; 10/20/2016, Vol. 11 Issue 10, p1-11, 11p

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