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Language : english Publisher : elsevier Subject : albumins Subject : blood plasma Subject : debrisoquin Subject : schistosomicides Subject : serum albumin
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Academic Journal

Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat.

  • Authors : Ishii M; Department of Pharmacology, University of Toronto, Faculty of Medicine, Medical Science Building, 8 Taddlecreek Road, M5S 1A8, Toronto, ONT, Canada.; Xu BQ

Subjects: Adrenergic Agents/Adrenergic Agents/Adrenergic Agents/*metabolism ; Alpha-Globulins/Alpha-Globulins/Alpha-Globulins/*pharmacology ; Cytochrome P-450 CYP2D6/Cytochrome P-450 CYP2D6/Cytochrome P-450 CYP2D6/*metabolism

  • Source: Toxicology letters [Toxicol Lett] 2001 Mar 08; Vol. 119 (3), pp. 219-25.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print Cited Medium: Print

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Academic Journal

Extrapolating in vitro metabolic interactions to isolated perfused liver: predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine.

  • Authors : Haddad S; Department of Biological Sciences, Centre TOXEN, Université du Québec à Montréal, Montréal, Québec, Canada. ; Poulin P

Subjects: Adrenergic alpha-Antagonists/Adrenergic alpha-Antagonists/Adrenergic alpha-Antagonists/*pharmacology ; Adrenergic beta-Antagonists/Adrenergic beta-Antagonists/Adrenergic beta-Antagonists/*pharmacology ; Debrisoquin/Debrisoquin/Debrisoquin/*pharmacology

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2010 Oct; Vol. 99 (10), pp. 4406-26.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium:

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Academic Journal

Chimeric mice with humanized liver.

  • Authors : Katoh M; Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.; Tateno C

Subjects: Liver*/Liver*/Liver*/drug effects ; Liver*/Liver*/Liver*/enzymology ; Liver*/Liver*/Liver*/metabolism

  • Source: Toxicology [Toxicology] 2008 Apr 03; Vol. 246 (1), pp. 9-17. Date of Electronic Publication: 2007 Nov 22.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.

  • Authors : Katoh M; Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-1192, Japan.; Sawada T

Subjects: Chimera* ; Models, Animal*; Cytochrome P-450 CYP2D6/Cytochrome P-450 CYP2D6/Cytochrome P-450 CYP2D6/*metabolism

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2007 Feb; Vol. 96 (2), pp. 428-37.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Print

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Academic Journal

Enantioselectivity of debrisoquine 4-hydroxylation in Brazilian Caucasian hypertensive patients phenotyped as extensive metabolizers.

  • Authors : Cerqueira PM; Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Brazil.; Mateus FH

Subjects: Chromatography, High Pressure Liquid*/Chromatography, High Pressure Liquid*/Chromatography, High Pressure Liquid*/methods; Antihypertensive Agents/Antihypertensive Agents/Antihypertensive Agents/*urine ; Debrisoquin/Debrisoquin/Debrisoquin/*urine

  • Source: Journal of chromatography. B, Biomedical sciences and applications [J Chromatogr B Biomed Sci Appl] 2000 Dec 01; Vol. 749 (2), pp. 153-61.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9714109 Publication Model: Print Cited Medium: Print

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Biography

The Paton Prize Award. The discovery of the debrisoquine hydroxylation polymorphism: scientific and clinical impact and consequences.

  • Authors : Smith RL; Molecular Toxicology, Imperial College School of Medicine, South Kensington, London, UK.

Subjects: Debrisoquin/Debrisoquin/Debrisoquin/*history ; Genetics/Genetics/Genetics/*history; Awards and Prizes Paton W

  • Source: Toxicology [Toxicology] 2001 Nov 01; Vol. 168 (1), pp. 11-9.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Separation and quantitation of debrisoquine and 4-hydroxydebrisoquine in human urine by capillary electrophoresis and high-performance liquid chromatography.

  • Authors : Cifuentes A; Departamento de Química Analítica, Nutrición y Bromatología, Universidad de La Laguna, Tenerife, Spain.; Valencia J

Subjects: Antihypertensive Agents/Antihypertensive Agents/Antihypertensive Agents/*urine ; Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/*methods ; Debrisoquin/Debrisoquin/Debrisoquin/*urine

  • Source: Journal of chromatography. A [J Chromatogr A] 1997 Aug 22; Vol. 778 (1-2), pp. 389-96.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print Cited Medium: Print

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Academic Journal

Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection.

  • Authors : Frye RF; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, PA 15261, USA.; Branch RA

Subjects: Debrisoquin/Debrisoquin/Debrisoquin/*analogs & derivatives; Calibration ; Chromatography, High Pressure Liquid

  • Source: Journal of chromatography. B, Biomedical applications [J Chromatogr B Biomed Appl] 1996 Feb 23; Vol. 677 (1), pp. 178-82.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421796 Publication Model: Print Cited Medium: Print

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Academic Journal

Acute effects of neuroleptics on unmedicated schizophrenic patients and controls.

  • Authors : Miller AL; Department of Psychiatry, University of Texas Health Science Center at San Antonio 78284-7792.; Maas JW

Subjects: Antipsychotic Agents/Antipsychotic Agents/Antipsychotic Agents/*pharmacology ; Debrisoquin/Debrisoquin/Debrisoquin/*pharmacology ; Schizophrenia/Schizophrenia/Schizophrenia/*drug therapy

  • Source: Biological psychiatry [Biol Psychiatry] 1993 Aug 01; Vol. 34 (3), pp. 178-87.Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print Cited Medium: Print

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Academic Journal

Gas chromatography/mass spectrometry assays for the determination of debrisoquine and sparteine metabolites in microsomal fractions of rat liver.

  • Authors : Ho JW; Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City 84108.; Moody DE

Subjects: Gas Chromatography-Mass Spectrometry*; Debrisoquin/Debrisoquin/Debrisoquin/*metabolism ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*metabolism

  • Source: Analytical biochemistry [Anal Biochem] 1992 Jun; Vol. 203 (2), pp. 348-51.Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print Cited Medium: Print

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  • 1-10 of  62 results for ""Debrisoquin""