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Academic Journal

Increased acid sphingomyelinase levels in pediatric patients with obesity.

  • Authors : Mameli C; Department of Pediatrics, Ospedale dei Bambini V. Buzzi, Via Castelvetro 32, Milan, Italy. .; Department of Biomedical and Clinical Science L. Sacco, Università Di Milano, Milan, Italy. .

Subjects: Obesity*/Obesity*/Obesity*/enzymology ; Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/metabolism; Adolescent

  • Source: Scientific reports [Sci Rep] 2022 Jun 29; Vol. 12 (1), pp. 10996. Date of Electronic Publication: 2022 Jun 29.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.

  • Authors : Garrido CM; Department of Biochemistry and Molecular Biology, School of Boonshoft Medical School, Wright State University, Dayton, OH, 45435, United States.; Henkels KM

Subjects: Saponins/Saponins/Saponins/*chemistry ; Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/*antagonists & inhibitors ; ras Proteins/ras Proteins/ras Proteins/*metabolism

  • Source: Scientific reports [Sci Rep] 2020 Jun 04; Vol. 10 (1), pp. 9120. Date of Electronic Publication: 2020 Jun 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1).

  • Authors : Jung JH; Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea.; Taniguchi K

Subjects: Drug Resistance, Neoplasm*; Ceramides/Ceramides/Ceramides/*metabolism ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*metabolism

  • Source: Scientific reports [Sci Rep] 2020 Apr 09; Vol. 10 (1), pp. 6124. Date of Electronic Publication: 2020 Apr 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients.

  • Authors : Pieragostino D; Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy.; Centre on Aging Sciences and Translational Medicine (Ce.S.I-MeT), University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy.

Subjects: Multiple Sclerosis/Multiple Sclerosis/Multiple Sclerosis/*pathology ; Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/*physiology ; Sphingomyelins/Sphingomyelins/Sphingomyelins/*physiology

  • Source: Scientific reports [Sci Rep] 2018 Feb 15; Vol. 8 (1), pp. 3071. Date of Electronic Publication: 2018 Feb 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver.

  • Authors : Chung HY; Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany.; Department of Anesthesiology and Intensive Care, Jena University Hospital, Am Klinikum 1, Jena, 07747, Germany.

Subjects: Desipramine/Desipramine/Desipramine/*pharmacology ; Liver/Liver/Liver/*drug effects ; Liver Cirrhosis/Liver Cirrhosis/Liver Cirrhosis/*prevention & control

  • Source: Scientific reports [Sci Rep] 2017 Sep 27; Vol. 7 (1), pp. 12348. Date of Electronic Publication: 2017 Sep 27.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR).

  • Authors : Stauffer BB; Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory + Children's Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA, 30322, USA.; Molecular and Systems Pharmacology program, Emory University, 201 Dowman Drive, Atlanta, GA, 20322, USA.

Subjects: Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*pharmacology ; Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/*antagonists & inhibitors ; Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/*pharmacology

  • Source: Scientific reports [Sci Rep] 2017 Jun 07; Vol. 7 (1), pp. 2931. Date of Electronic Publication: 2017 Jun 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α.

  • Authors : Al-Rashed F; Immunology and Microbiology Department, Dasman Diabetes Institute, Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait, Kuwait.; Ahmad Z

Subjects: Macrophages/Macrophages/Macrophages/*drug effects ; Monocytes/Monocytes/Monocytes/*drug effects ; Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/*metabolism

  • Source: Scientific reports [Sci Rep] 2020 Oct 08; Vol. 10 (1), pp. 16802. Date of Electronic Publication: 2020 Oct 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase.

  • Authors : Rana S; Department of Radiation Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.; Espinosa-Diez C

Subjects: MicroRNAs/MicroRNAs/MicroRNAs/*radiation effects ; Neovascularization, Pathologic/Neovascularization, Pathologic/Neovascularization, Pathologic/*metabolism ; Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/Sphingomyelin Phosphodiesterase/*metabolism

  • Source: Scientific reports [Sci Rep] 2020 Mar 27; Vol. 10 (1), pp. 5581. Date of Electronic Publication: 2020 Mar 27.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.

Subjects: ADAM17 Protein/ADAM17 Protein/ADAM17 Protein/*antagonists & inhibitors ; Hordeum/Hordeum/Hordeum/*chemistry ; Renal Insufficiency, Chronic/Renal Insufficiency, Chronic/Renal Insufficiency, Chronic/*diet therapy

  • Source: Scientific reports [Sci Rep] 2019 Nov 28; Vol. 9 (1), pp. 17810. Date of Electronic Publication: 2019 Nov 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.

  • Authors : Rojas C; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.; Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.

Subjects: Astrocytes/Astrocytes/Astrocytes/*drug effects ; Brain/Brain/Brain/*drug effects ; Encephalitis/Encephalitis/Encephalitis/*drug therapy

  • Source: Scientific reports [Sci Rep] 2018 Dec 07; Vol. 8 (1), pp. 17715. Date of Electronic Publication: 2018 Dec 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  56 results for ""Sphingomyelin Phosphodiesterase""