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Academic Journal

Integrative pan-cancer analysis of MEK1 aberrations and the potential clinical implications.

  • Authors : Zhou Z; Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Peng B

Subjects: Mutation*; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*genetics ; Neoplasms/Neoplasms/Neoplasms/*genetics

  • Source: Scientific reports [Sci Rep] 2021 Sep 15; Vol. 11 (1), pp. 18366. Date of Electronic Publication: 2021 Sep 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases.

  • Authors : Ordan M; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.; Pallara C

Subjects: Gene Expression Regulation, Enzymologic*; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*genetics ; MAP Kinase Kinase 2/MAP Kinase Kinase 2/MAP Kinase Kinase 2/*genetics

  • Source: Scientific reports [Sci Rep] 2018 Aug 07; Vol. 8 (1), pp. 11830. Date of Electronic Publication: 2018 Aug 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib.

  • Authors : Novo SM; Edinburgh Cancer Research Centre and MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, Scotland, EH4 2XU, UK.; Wedge SR

Subjects: Benzimidazoles/Benzimidazoles/Benzimidazoles/*therapeutic use ; Colon/Colon/Colon/*drug effects ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy

  • Source: Scientific reports [Sci Rep] 2017 Sep 20; Vol. 7 (1), pp. 12020. Date of Electronic Publication: 2017 Sep 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The limitations of targeting MEK signalling in Glioblastoma therapy.

  • Authors : Selvasaravanan KD; Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.

Subjects: Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology ; Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*therapy ; Glioblastoma/Glioblastoma/Glioblastoma/*therapy

  • Source: Scientific reports [Sci Rep] 2020 May 04; Vol. 10 (1), pp. 7401. Date of Electronic Publication: 2020 May 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Arteriovenous Malformation MAP2K1 Mutation Causes Local Cartilage Overgrowth by a Cell-Non Autonomous Mechanism.

  • Authors : Konczyk DJ; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, USA.; Goss JA

Subjects: Mutation*; Arteriovenous Malformations/Arteriovenous Malformations/Arteriovenous Malformations/*complications ; Cartilage Diseases/Cartilage Diseases/Cartilage Diseases/*etiology

  • Source: Scientific reports [Sci Rep] 2020 Mar 10; Vol. 10 (1), pp. 4428. Date of Electronic Publication: 2020 Mar 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma.

  • Authors : Jain AP; Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India.; School of Biotechnology, Kalinga Institute of Industrial Technology, Odisha, 751024, India.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use ; Erlotinib Hydrochloride/Erlotinib Hydrochloride/Erlotinib Hydrochloride/*therapeutic use ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*antagonists & inhibitors

  • Source: Scientific reports [Sci Rep] 2019 Dec 11; Vol. 9 (1), pp. 18793. Date of Electronic Publication: 2019 Dec 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Genome-wide Identification of Jatropha curcas MAPK, MAPKK, and MAPKKK Gene Families and Their Expression Profile Under Cold Stress.

  • Authors : Wang H; Center for Yunnan Plateau Biological Resources Protection and Utilization, Qujing Normal University, Qujing, Yunnan, 655011, China.; Key Laboratory of Yunnan Province Universities of the Diversity and Ecological Adaptive Evolution for Animals and Plants on YunGui Plateau, Qujing Normal University, Qujing, Yunnan, 655011, China.

Subjects: Cold-Shock Response/Cold-Shock Response/Cold-Shock Response/*genetics ; Jatropha/Jatropha/Jatropha/*genetics ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*genetics

  • Source: Scientific reports [Sci Rep] 2018 Nov 01; Vol. 8 (1), pp. 16163. Date of Electronic Publication: 2018 Nov 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression.

  • Authors : Giguère H; Département de Pharmacologie et Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.; Dumont AA

Subjects: GTPase-Activating Proteins/GTPase-Activating Proteins/GTPase-Activating Proteins/*genetics ; Hypertrophy/Hypertrophy/Hypertrophy/*genetics ; Integrin beta1/Integrin beta1/Integrin beta1/*genetics Leukocyte Adhesion Deficiency, Type III

  • Source: Scientific reports [Sci Rep] 2018 Sep 11; Vol. 8 (1), pp. 13605. Date of Electronic Publication: 2018 Sep 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeting BMK1 Impairs the Drug Resistance to Combined Inhibition of BRAF and MEK1/2 in Melanoma.

  • Authors : Song C; Department of Oncology, Second Affiliated Hospital, Institute of Cancer Stem Cell, DaLian Medical University, 9 Western Lvshun South Road, Dalian, Liaoning 116044, China.; Wang L

Subjects: Drug Resistance, Neoplasm*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*administration & dosage ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*antagonists & inhibitors

  • Source: Scientific reports [Sci Rep] 2017 Apr 07; Vol. 7, pp. 46244. Date of Electronic Publication: 2017 Apr 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis.

  • Authors : Procaccia S; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel.; Ordan M

Subjects: Cell Movement* ; Protein Processing, Post-Translational*; Forkhead Box Protein O1/Forkhead Box Protein O1/Forkhead Box Protein O1/*metabolism

  • Source: Scientific reports [Sci Rep] 2017 Feb 22; Vol. 7, pp. 43078. Date of Electronic Publication: 2017 Feb 22.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  28 results for ""MAP Kinase Kinase 1""