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Academic Journal

Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.

  • Authors : Kanai R; Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.; Cornelius F

Subjects: Cardiac Glycosides*/Cardiac Glycosides*/Cardiac Glycosides*/pharmacology ; Cardiotonic Agents*/Cardiotonic Agents*/Cardiotonic Agents*/pharmacology ; Ouabain*/Ouabain*/Ouabain*/pharmacology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Apr 12; Vol. 119 (15), pp. e2123226119. Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform.

Subjects: Brain Ischemia/Brain Ischemia/Brain Ischemia/*pathology ; Brain Ischemia/Brain Ischemia/Brain Ischemia/*prevention & control ; Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*pharmacology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2006 Jul 05; Vol. 103 (27), pp. 10461-10466. Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print

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Academic Journal

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.

  • Authors : Langenhan JM; Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA.; Peters NR

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*chemistry; Animals

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Aug 30; Vol. 102 (35), pp. 12305-10. DatePublisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print

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Academic Journal

Structural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMR.

  • Authors : Middleton DA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom. ; Rankin S

Subjects: Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*metabolism ; Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/*metabolism; Carbohydrate Conformation

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2000 Dec 05; Vol. 97 (25), pp. 13602-7.Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.

  • Authors : Kanai R; Institute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan.; Cornelius F

Subjects: Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*chemistry ; Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*pharmacology ; Sodium/Sodium/Sodium/*chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 07; Vol. 118 (1).Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.

  • Authors : Zhang H; Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Qian DZ

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*pharmacology ; Digoxin/Digoxin/Digoxin/*pharmacology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 Dec 16; Vol. 105 (50), pp. 19579-86. DatePublisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The sodium pump and hypertension: a physiological role for the cardiac glycoside binding site of the Na,K-ATPase.

  • Authors : Kaplan JH; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Molecular Biology Research Building, 900 South Ashland Avenue, Chicago, IL 60607, USA.

Subjects: Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*metabolism ; Hypertension/Hypertension/Hypertension/*etiology ; Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Nov 01; Vol. 102 (44), pp. 15723-4. Date Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print

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Academic Journal

Widespread convergence in toxin resistance by predictable molecular evolution.

  • Authors : Ujvari B; Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia; Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia

Subjects: Evolution, Molecular*; Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*toxicity; Bufanolides/Bufanolides/Bufanolides/chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Sep 22; Vol. 112 (38), pp. 11911-6. Date Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The cardiac glycoside binding site on the Na,K-ATPase alpha2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle.

  • Authors : Radzyukevich TL; Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0576, USA.; Lingrel JB

Subjects: Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*metabolism ; Isoenzymes/Isoenzymes/Isoenzymes/*metabolism ; Muscle, Skeletal/Muscle, Skeletal/Muscle, Skeletal/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2009 Feb 24; Vol. 106 (8), pp. 2565-70. Date Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.

  • Authors : Dostanic-Larson I; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.; Van Huysse JW

Subjects: Blood Pressure*; Cardiac Glycosides/Cardiac Glycosides/Cardiac Glycosides/*metabolism ; Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/Sodium-Potassium-Exchanging ATPase/*physiology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Nov 01; Vol. 102 (44), pp. 15845-50. DatePublisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print

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