Search Results

High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses.

• Authors : Mudhasani R; Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.; Kota KP

Subjects: Small Molecule Libraries*; Image Processing, Computer-Assisted/Image Processing, Computer-Assisted/Image Processing, Computer-Assisted/*methods ; Protease Inhibitors/Protease Inhibitors/Protease Inhibitors/*pharmacology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2014 Aug 21; Vol. 8 (8), pp. e3095. Date of Electronic Publication: 2014 Aug 21 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

Record details

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.

• Authors : Sharlow ER; University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, USA.; Close D

Subjects: Antiprotozoal Agents/Antiprotozoal Agents/Antiprotozoal Agents/*pharmacology ; High-Throughput Screening Assays/High-Throughput Screening Assays/High-Throughput Screening Assays/*methods ; Leishmania major/Leishmania major/Leishmania major/*drug effects

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2009 Nov 03; Vol. 3 (11), pp. e540. Date of Electronic Publication: 2009 Nov 03.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: Electronic Cited Medium: Internet

Record details

High Content Screening of a Kinase-Focused Library Reveals Compounds Broadly-Active against Dengue Viruses.

• Authors : Cruz, Deu John M.¹ (AUTHOR); Koishi, Andrea Cristine^2,3 (AUTHOR); Taniguchi, Juliana Bosso⁴ (AUTHOR)

Subjects: *DENGUE viruses; *CHEMICAL libraries; *HEPATITIS C virusSOUTH America

• Source: PLoS Neglected Tropical Diseases. 2/21/2013, Vol. 7 Issue 2, p1-13. 13p. 1 Color Photograph, 3 Diagrams, 1 Chart, 1 Graph.

Record details

In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds.

• Authors : Canavaci, Adriana M. C.¹ (AUTHOR); Bustamante, Juan M.¹ (AUTHOR); Padilla, Angel M.¹ (AUTHOR)

Subjects: *HIGH throughput screening (Drug development); *CHEMICAL libraries; *LUCIFERASES

• Source: PLoS Neglected Tropical Diseases. 7/13/2010, Vol. 4 Issue 7, p1-13. 13p.

Record details

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening.

• Authors : Abdulla, Maha-Hamadien¹ (AUTHOR); Ruelas, Debbie S.¹ (AUTHOR); Wolff, Brian² (AUTHOR)

Subjects: *DRUG discovery; *CHEMICAL libraries; *MEDICAL screening

• Source: PLoS Neglected Tropical Diseases. 7/14/2009, Vol. 3 Issue 7, p1-14. 14p.

Record details

Design of the Global Health chemical diversity library v2 for screening against infectious diseases.

• Authors : Wilson, Caroline¹ (AUTHOR); Gardner, J. Mark F.² (AUTHOR); Gray, David W.¹ (AUTHOR)

Subjects: *CHEMICAL libraries; *MEDICAL screening; *COMMUNICABLE diseasesBILL & Melinda Gates Foundation BILL & Melinda Gates Foundation BILL & Melinda Gates Foundation 127256381 ; WELLCOME Trust (London, England)

• Source: PLoS Neglected Tropical Diseases. 12/27/2023, Vol. 17 Issue 12, p1-13. 13p.

Record details

An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors.

• Authors : Fernandes Silva, Suélen; Hollunder Klippel, Angélica; Sigurdardóttir, Sunniva

• Source: PLoS Neglected Tropical Diseases; 12/2/2024, Vol. 18 Issue 12, p1-25, 25p

Record details

High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.

• Authors : Mansour, Nuha R.; Paveley, Ross; Gardner, J. Mark F.

Subjects: HIGH throughput screening (Drug development); SCHISTOSOMIASIS treatment; LEAD compounds

• Source: PLoS Neglected Tropical Diseases; 4/29/2016, Vol. 10 Issue 4, p1-12, 12p

Record details

Luciferase-Expressing Leishmania infantum Allows the Monitoring of Amastigote Population Size, In Vivo, Ex Vivo and In Vitro.

• Authors : Michel, Grégory^1,2,3,4 (AUTHOR) ; Ferrua, Bernard^1,3 (AUTHOR); Lang, Thierry⁵ (AUTHOR)

Subjects: *LEISHMANIA infantum; *CHEMICAL libraries; *VISCERAL leishmaniasis

• Source: PLoS Neglected Tropical Diseases. 9/13/2011, Vol. 5 Issue 9, p1-7. 7p.

Record details

Comparison of Microscopy and Alamar Blue Reduction in a Larval Based Assay for Schistosome Drug Screening.

• Authors : Mansour, Nuha R.¹ (AUTHOR); Bickle, Quentin D.¹ (AUTHOR)

Subjects: *HIGH throughput screening (Drug development); *CHEMICAL libraries; *DRUG discovery

• Source: PLoS Neglected Tropical Diseases. 8/10/2010, Vol. 4 Issue 8, p1-8. 8p.

Record details