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Academic Journal

Structure-guided combination therapy to potently improve the function of mutant CFTRs.

  • Authors : Veit G; Department of Physiology, McGill University, Montréal, Quebec, Canada. .; Xu H

Subjects: Cystic Fibrosis/Cystic Fibrosis/Cystic Fibrosis/*drug therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/*chemistry ; Protein Folding/Protein Folding/Protein Folding/*drug effects

  • Source: Nature medicine [Nat Med] 2018 Nov; Vol. 24 (11), pp. 1732-1742. Date of Electronic Publication: 2018 Oct 08.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.

Subjects: Neoplasms/Neoplasms/Neoplasms/*drug therapy ; Neoplasms/Neoplasms/Neoplasms/*genetics ; Piperazines/Piperazines/Piperazines/*pharmacology

  • Source: Nature medicine [Nat Med] 2018 May; Vol. 24 (4), pp. 497-504. Date of Electronic Publication: 2018 Feb 19.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.

  • Authors : Schulte ML; Vanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Subjects: Amino Acid Transport System ASC/Amino Acid Transport System ASC/Amino Acid Transport System ASC/*antagonists & inhibitors ; Glutamine/Glutamine/Glutamine/*metabolism ; Neoplasms/Neoplasms/Neoplasms/*drug therapy

  • Source: Nature medicine [Nat Med] 2018 Feb; Vol. 24 (2), pp. 194-202. Date of Electronic Publication: 2018 Jan 15.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Periodical

Bringing RNA into the fold: Small molecules find new targets in RNA to combat disease.

Subjects: Drug Delivery Systems*; RNA/RNA/RNA/*chemistry ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: Nature medicine [Nat Med] 2017 May 05; Vol. 23 (5), pp. 532-534.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.

Subjects: Anti-HIV Agents/Anti-HIV Agents/Anti-HIV Agents/*pharmacology ; Capsid Proteins/Capsid Proteins/Capsid Proteins/*antagonists & inhibitors ; HIV Infections/HIV Infections/HIV Infections/*drug therapy

  • Source: Nature medicine [Nat Med] 2019 Sep; Vol. 25 (9), pp. 1377-1384. Date of Electronic Publication: 2019 Sep 09.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.

  • Authors : Wang C; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Subjects: Apolipoprotein E4/Apolipoprotein E4/Apolipoprotein E4/*toxicity ; Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/*drug effects ; Neurons/Neurons/Neurons/*drug effects

  • Source: Nature medicine [Nat Med] 2018 May; Vol. 24 (5), pp. 647-657. Date of Electronic Publication: 2018 Apr 09.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

Subjects: Neoplasms/Neoplasms/Neoplasms/*drug therapy ; Nucleosides/Nucleosides/Nucleosides/*pharmacology ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: Nature medicine [Nat Med] 2018 Feb; Vol. 24 (2), pp. 186-193. Date of Electronic Publication: 2018 Jan 15.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.

  • Authors : van de Haar J; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Subjects: Evolution, Molecular*; Biomarkers, Tumor/Biomarkers, Tumor/Biomarkers, Tumor/*genetics ; Neoplasm Proteins/Neoplasm Proteins/Neoplasm Proteins/*genetics

  • Source: Nature medicine [Nat Med] 2021 Sep; Vol. 27 (9), pp. 1553-1563. Date of Electronic Publication: 2021 Aug 09.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.

Subjects: TYPE 2 diabetes treatment; TREATMENT of diabetes; TYPE 1 diabetes

  • Source: Nature Medicine; Apr2015, Vol. 21 Issue 4, p383-388, 6p, 4 Graphs

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Academic Journal

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.

  • Authors : Graham WV; Department of Pathology, University of Chicago, Chicago, IL, USA.; Laboratory of Chemical Biology & Signal Transduction, The Rockefeller University, New York, NY, USA.

Subjects: Homeostasis*/Homeostasis*/Homeostasis*/drug effects; Intestinal Mucosa/Intestinal Mucosa/Intestinal Mucosa/*metabolism ; Intracellular Space/Intracellular Space/Intracellular Space/*enzymology

  • Source: Nature medicine [Nat Med] 2019 Apr; Vol. 25 (4), pp. 690-700. Date of Electronic Publication: 2019 Apr 01.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  40 results for ""Small Molecule Libraries""