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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.

• Authors : Shapira T; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Monreal IA

Subjects: COVID-19*/COVID-19*/COVID-19*/prevention & control ; COVID-19*/COVID-19*/COVID-19*/virology ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects SARS-CoV-2 variants

• Source: Nature [Nature] 2022 May; Vol. 605 (7909), pp. 340-348. Date of Electronic Publication: 2022 Mar 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.

• Authors : Lamarre D; Department of Biological Sciences Boehringer Ingelheim (Canada) Ltd, Laval, Québec, H7S 2G5, Canada. ; Anderson PC

Subjects: Macrocyclic Compounds* ; Quinolines*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*therapeutic use

• Source: Nature [Nature] 2003 Nov 13; Vol. 426 (6963), pp. 186-9. Date of Electronic Publication: 2003 Oct 26.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Structure of a serpin-protease complex shows inhibition by deformation.

• Authors : Huntington JA; Department of Haematology, University of Cambridge, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, UK. ; Read RJ

Subjects: Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*chemistry ; Trypsin/Trypsin/Trypsin/*chemistry ; alpha 1-Antitrypsin/alpha 1-Antitrypsin/alpha 1-Antitrypsin/*chemistry

• Source: Nature [Nature] 2000 Oct 19; Vol. 407 (6806), pp. 923-6.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Peptide exosite inhibitors of factor VIIa as anticoagulants.

• Authors : Dennis MS; Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.; Eigenbrot C

Subjects: Anticoagulants/Anticoagulants/Anticoagulants/*pharmacology ; Factor VIIa/Factor VIIa/Factor VIIa/*antagonists & inhibitors ; Oligopeptides/Oligopeptides/Oligopeptides/*pharmacology

• Source: Nature [Nature] 2000 Mar 30; Vol. 404 (6777), pp. 465-70.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.

• Authors : Ponte P; California Biotechnology, Inc., Mountain View 94043.; Gonzalez-DeWhitt P

Subjects: Serine Proteinase Inhibitors*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid/Amyloid/Amyloid/*genetics

• Source: Nature [Nature] 1988 Feb 11; Vol. 331 (6156), pp. 525-7.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor.

• Authors : Paetzel M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada.; Dalbey RE

Subjects: Lactams* ; Membrane Proteins*; Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*chemistry

• Source: Nature [Nature] 1998 Nov 12; Vol. 396 (6707), pp. 186-90.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Design of potent selective zinc-mediated serine protease inhibitors.

• Authors : Katz BA; Arris Pharmaceutical Corporation, South San Francisco, California 94080, USA. ; Clark JM

Subjects: Benzimidazoles/Benzimidazoles/Benzimidazoles/*chemistry ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*chemistry ; Zinc/Zinc/Zinc/*chemistry

• Source: Nature [Nature] 1998 Feb 05; Vol. 391 (6667), pp. 608-12.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Structural biology: Serpins' mystery solved.

• Authors : Whisstock, James C.¹ ; Bottomley, Stephen P.¹

Subjects: *SERINE proteinase inhibitors; *SERPINS; *POLYMERSALZHEIMER, Alois, 1864-1915

• Source: Nature. 10/30/2008, Vol. 455 Issue 7217, p1189-1190. 2p. 1 Diagram.

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Plakalbumin, α1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis

• Authors : Carrell, Robin W.; Owen, Maurice C.

• Source: Nature; October 1985, Vol. 317 Issue: 6039 p730-732, 3p

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Familial dementia caused by polymerization of mutant neuroserpin.

• Authors : Davis, Richard L.; Shrimpton, Antony E.; Holohan, Peter D.

Subjects: ENCEPHALITIS; FAMILIAL diseases; DEMENTIA

• Source: Nature; 9/23/1999, Vol. 401 Issue 6751, p376, 4p, 2 Color Photographs, 4 Black and White Photographs, 4 Diagrams, 1 Graph

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