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An atomic structure of human γ-secretase.

• Authors : Bai XC; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.; Yan C

Subjects: Cryoelectron Microscopy*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*ultrastructure

• Source: Nature [Nature] 2015 Sep 10; Vol. 525 (7568), pp. 212-217. Date of Electronic Publication: 2015 Aug 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis.

• Authors : Zhang, Zhuohua; Hartmann, Henrike; Viet Minh Do

Subjects: PRESENILINS; GENETICS of Alzheimer's disease; MEMBRANE proteins

• Source: Nature. 10/15/1998, Vol. 395 Issue 6703, p698. 5p. 6 Color Photographs, 9 Black and White Photographs, 4 Graphs.

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Structure of a presenilin family intramembrane aspartate protease.

• Authors : Li X; Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Dang S

Subjects: Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*chemistry ; Methanomicrobiaceae/Methanomicrobiaceae/Methanomicrobiaceae/*enzymology ; Presenilins/Presenilins/Presenilins/*chemistry

• Source: Nature [Nature] 2013 Jan 03; Vol. 493 (7430), pp. 56-61. Date of Electronic Publication: 2012 Dec 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Presenilin-1 mutations on Alzheimer's disease.

• Authors : Russo, C.; Schettini, G.; Saido, T.C.

Subjects: GENETICS of Alzheimer's disease; PRESENILINS; GENETIC mutation

• Source: Nature. 6/1/2000, Vol. 405 Issue 6786, p531. 2p. 2 Color Photographs, 3 Diagrams, 1 Graph.

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

• Authors : De Strooper, Bart; Annaert, Wim; Cupers, Philippe

Subjects: PRESENILINS; PROTEOLYTIC enzymes; NOTCH proteins

• Source: Nature. 4/8/1999, Vol. 398 Issue 6727, p518. 5p. 4 Color Photographs, 11 Black and White Photographs, 1 Diagram, 1 Graph.

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Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP.

• Authors : Kamal, Adeela; Almenar-Queralt, Angels; LeBlanc, James F.

• Source: Nature. December 6, 2001, Vol. 414 Issue 6864, p643, 6 p.

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

• Authors : Wolfe, Michael S.; Xia, Weiming; Ostaszewski, Beth L.

Subjects: ASPARTATE aminotransferase; AMYLOID beta-protein; ALZHEIMER'S disease

• Source: Nature; 4/8/1999, Vol. 398 Issue 6727, p513, 5p, 14 Black and White Photographs, 1 Diagram, 2 Graphs

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Presenilins are essential for regulating neurotransmitter release.

• Authors : Chen Zhang; Bei Wu; Beglopoulos, Vassilios

Subjects: PRESENILINS; ALZHEIMER'S disease; NEURAL transmission

• Source: Nature. 7/30/2009, Vol. 460 Issue 7255, p632-636. 5p. 4 Graphs.

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The role of presenilin cofactors in the ?-secretase complex.

• Authors : Takasugi, Nobumasa; Tomita, Taisuke; Hayashi, Ikuo

Subjects: PRESENILINS; PROTEINS; ALZHEIMER'S disease

• Source: Nature. 3/27/2003, Vol. 422 Issue 6930, p438. 4p.

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and BetaAPP processing.

• Authors : Yu, Gang; Nishimura, Masaki; Arawaka, Shigeki

Subjects: GLYCOPROTEINS; PRESENILINS; CELLULAR signal transduction

• Source: Nature. 9/7/2000, Vol. 407 Issue 6800, p48. 7p. 1 Color Photograph, 6 Diagrams.

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