Search Results

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.

• Authors : Kang E; Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA.; Division of Reproductive &Developmental Sciences, Oregon National Primate Research Center, Oregon Health &Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA.

Subjects: Mutation*; DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics ; DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*therapeutic use

• Source: Nature [Nature] 2016 Dec 08; Vol. 540 (7632), pp. 270-275. Date of Electronic Publication: 2016 Nov 30.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.

• Authors : Hyslop LA; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life, Times Square, Newcastle upon Tyne NE1 3BZ, UK.; Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life, Times Square, Newcastle upon Tyne NE1 4EP, UK.

Subjects: Nuclear Transfer Techniques*; DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics ; Mitochondrial Diseases/Mitochondrial Diseases/Mitochondrial Diseases/*genetics

• Source: Nature [Nature] 2016 Jun 16; Vol. 534 (7607), pp. 383-6. Date of Electronic Publication: 2016 Jun 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Three-person embryos may fail to vanquish mutant mitochondria.

• Authors : Callaway E

Subjects: Mitochondrial Replacement Therapy*/Mitochondrial Replacement Therapy*/Mitochondrial Replacement Therapy*/adverse effects ; Mitochondrial Replacement Therapy*/Mitochondrial Replacement Therapy*/Mitochondrial Replacement Therapy*/legislation & jurisprudence ; Mitochondrial Replacement Therapy*/Mitochondrial Replacement Therapy*/Mitochondrial Replacement Therapy*/methods

• Source: Nature [Nature] 2016 May 26; Vol. 533 (7604), pp. 445-6.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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US panel greenlights creation of male 'three-person' embryos.

• Authors : Reardon S

Subjects: Patient Safety*; Embryo Research/Embryo Research/Embryo Research/*legislation & jurisprudence ; Genetic Therapy/Genetic Therapy/Genetic Therapy/*legislation & jurisprudence

• Source: Nature [Nature] 2016 Feb 11; Vol. 530 (7589), pp. 142.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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The hidden risks for 'three-person' babies.

• Authors : Hamilton G

Subjects: Evolution, Molecular*; Biological Therapy/Biological Therapy/Biological Therapy/*adverse effects ; Cell Nucleus/Cell Nucleus/Cell Nucleus/*genetics

• Source: Nature [Nature] 2015 Sep 24; Vol. 525 (7570), pp. 444-6.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Power play.

Subjects: Bioethical Issues* ; Practice Guidelines as Topic*; Mitochondria/Mitochondria/Mitochondria/*transplantation

• Source: Nature [Nature] 2015 Sep 24; Vol. 525 (7570), pp. 425-6.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Metabolic rescue in pluripotent cells from patients with mtDNA disease.

• Authors : Ma H; 1] Center for Embryonic Cell and Gene Therapy, Oregon Health &Science University, 3303 S.W. Bond Avenue, Portland, Oregon 97239, USA [2] Division of Reproductive &Developmental Sciences, Oregon National Primate Research Center, Oregon Health &Science University, 505 N.W. 185th Avenue, Beaverton, Oregon 97006, USA.; Folmes CD

Subjects: DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics ; Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/*metabolism ; Mitochondria/Mitochondria/Mitochondria/*genetics

• Source: Nature [Nature] 2015 Aug 13; Vol. 524 (7564), pp. 234-8. Date of Electronic Publication: 2015 Jul 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Regulators weigh benefits of 'three-parent' fertilization.

• Authors : Hayden EC

Subjects: Parents*; Extrachromosomal Inheritance/Extrachromosomal Inheritance/Extrachromosomal Inheritance/*genetics ; Fertilization in Vitro/Fertilization in Vitro/Fertilization in Vitro/*adverse effects

• Source: Nature [Nature] 2013 Oct 17; Vol. 502 (7471), pp. 284-5.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Reproductive therapy: HFEA responds on germline therapy.

• Authors : Thompson P

Subjects: DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics ; Extrachromosomal Inheritance/Extrachromosomal Inheritance/Extrachromosomal Inheritance/*genetics ; Genetic Engineering/Genetic Engineering/Genetic Engineering/*ethics

• Source: Nature [Nature] 2013 Aug 15; Vol. 500 (7462), pp. 276.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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A slippery slope to human germline modification.

• Authors : Darnovsky M; Center for Genetics and Society, Berkeley, California, USA.

Subjects: DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics ; Extrachromosomal Inheritance/Extrachromosomal Inheritance/Extrachromosomal Inheritance/*genetics ; Genetic Engineering/Genetic Engineering/Genetic Engineering/*ethics

• Source: Nature [Nature] 2013 Jul 11; Vol. 499 (7457), pp. 127.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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