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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.

• Authors : Hur JY; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Frost GR

Subjects: Immunity, Innate*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*immunology ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism

• Source: Nature [Nature] 2020 Oct; Vol. 586 (7831), pp. 735-740. Date of Electronic Publication: 2020 Sep 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Structural basis of Notch recognition by human γ-secretase.

• Authors : Yang G; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.; Zhou R

Subjects: Cryoelectron Microscopy*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*ultrastructure

• Source: Nature [Nature] 2019 Jan; Vol. 565 (7738), pp. 192-197. Date of Electronic Publication: 2018 Dec 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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An atomic structure of human γ-secretase.

• Authors : Bai XC; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.; Yan C

Subjects: Cryoelectron Microscopy*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*ultrastructure

• Source: Nature [Nature] 2015 Sep 10; Vol. 525 (7568), pp. 212-217. Date of Electronic Publication: 2015 Aug 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

• Authors : Willem M; Biomedical Center (BMC), Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Tahirovic S

Subjects: Proteolysis*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism

• Source: Nature [Nature] 2015 Oct 15; Vol. 526 (7573), pp. 443-7. Date of Electronic Publication: 2015 Aug 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Three-dimensional structure of human γ-secretase.

• Authors : Lu P; Ministry of Education Key Laboratory of Protein Science, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.; Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.

Subjects: Models, Molecular*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry; Cryoelectron Microscopy

• Source: Nature [Nature] 2014 Aug 14; Vol. 512 (7513), pp. 166-170. Date of Electronic Publication: 2014 Jun 29.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Biochemistry: Molecular cloaking devices.

• Authors : Kodadek T

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*chemistry

• Source: Nature [Nature] 2008 Jun 12; Vol. 453 (7197), pp. 861-2.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Substrate-targeting gamma-secretase modulators.

• Authors : Kukar TL; Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. ; Ladd TB

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*chemistry

• Source: Nature [Nature] 2008 Jun 12; Vol. 453 (7197), pp. 925-9.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Alzheimer's disease: Selectively tuning gamma-secretase.

• Authors : St George-Hyslop P; Schmitt-Ulms G

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Proteins/Proteins/Proteins/*metabolism

• Source: Nature [Nature] 2010 Sep 02; Vol. 467 (7311), pp. 36-7.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Agricola

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Low-dose metformin targets the lysosomal AMPK pathway through PEN2.

• Authors : Ma T; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.; Tian X

Subjects: Hypoglycemic Agents*/Hypoglycemic Agents*/Hypoglycemic Agents*/administration & dosage ; Hypoglycemic Agents*/Hypoglycemic Agents*/Hypoglycemic Agents*/metabolism ; Hypoglycemic Agents*/Hypoglycemic Agents*/Hypoglycemic Agents*/pharmacology

• Source: Nature [Nature] 2022 Mar; Vol. 603 (7899), pp. 159-165. Date of Electronic Publication: 2022 Feb 23.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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