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Academic Journal

Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/cerebrospinal fluid ; tau Proteins*/tau Proteins*/tau Proteins*/cerebrospinal fluid ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/cerebrospinal fluid

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Oct 08; Vol. 19 (1), pp. 66. Date of Electronic Publication: 2024 Oct 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer's disease.

  • Authors : Ishii A; Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-3401, USA.; Pathoulas JA

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Nov 16; Vol. 19 (1), pp. 83. Date of Electronic Publication: 2024 Nov 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity.

  • Authors : Yao AY; Department of Neuroscience, University of Connecticut Health, Farmington, CT, USA.; Yan R

Subjects: Alzheimer Disease* ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2020 Nov 12; Vol. 15 (1), pp. 69. Date of Electronic Publication: 2020 Nov 12.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.

  • Authors : Serneels L; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.

Subjects: Alzheimer Disease* ; Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/genetics ; Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/Amyloid beta-Protein Precursor*/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2020 Oct 19; Vol. 15 (1), pp. 60. Date of Electronic Publication: 2020 Oct 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.

  • Authors : Johnson ECB; Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA, 94158, USA.; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94158, USA.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*pathology

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2020 Sep 14; Vol. 15 (1), pp. 53. Date of Electronic Publication: 2020 Sep 14.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.

  • Authors : Zhang X; Department of Neurobiology, The University of Chicago, 947 E. 58th St. MC0928, Chicago, Il 60637, USA. .; Yu CJ

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*chemistry; Amino Acid Sequence

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Aug 22; Vol. 10, pp. 39. Date of Electronic Publication: 2015 Aug 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

  • Authors : Neumann U; Neuroscience, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland. .; Rueeger H

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*antagonists & inhibitors

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Sep 03; Vol. 10, pp. 44. Date of Electronic Publication: 2015 Sep 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Jan 07; Vol. 10, pp. 1. Date of Electronic Publication: 2015 Jan 07.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.

  • Authors : Rogers K; EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA 02472, USA.; Felsenstein KM

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*enzymology ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*drug effects ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*drug effects

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2012 Dec 18; Vol. 7, pp. 61. Date of Electronic Publication: 2012 Dec 18.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.

  • Authors : Zhao Y; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, People's Republic of China.; Wang Y

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*genetics ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*genetics ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*genetics

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2012 Jun 18; Vol. 7, pp. 30. Date of Electronic Publication: 2012 Jun 18.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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  • 1-10 of  86 results for ""Amyloid Precursor Protein Secretases""