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  • 1-10 of  16 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""

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Academic Journal

6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2-(1H)quinolinone (cilostazol), a phosphodiesterase type 3 inhibitor, reduces infarct size via activation of mitochondrial Ca2+-activated K+ channels in rabbit hearts.

  • Authors : Fukasawa M; Department of Pharmacology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.; Nishida H

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism ; Mitochondria, Heart/Mitochondria, Heart/Mitochondria, Heart/*drug effects ; Myocardial Infarction/Myocardial Infarction/Myocardial Infarction/*drug therapy

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2008 Jul; Vol. 326 (1), pp. 100-4. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.

  • Authors : Gobejishvili L; Department of Internal Medicine (L.G., S.B., J.Z., D.V.A., C.J.M.) and Department of Pharmacology and Toxicology (S.B., D.V.A., C.J.M.), University of Louisville, Louisville, Kentucky; Department of Surgery, University of Louisville Medical Center, Louisville, Kentucky (Y.L.)

Subjects: Bile Duct Diseases/Bile Duct Diseases/Bile Duct Diseases/*prevention & control ; Cyclic Nucleotide Phosphodiesterases, Type 4/Cyclic Nucleotide Phosphodiesterases, Type 4/Cyclic Nucleotide Phosphodiesterases, Type 4/*physiology ; Liver Cirrhosis, Experimental/Liver Cirrhosis, Experimental/Liver Cirrhosis, Experimental/*pathology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2013 Oct; Vol. 347 (1), pp. 80-90. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Natriuretic peptide-induced catecholamine release from cardiac sympathetic neurons: inhibition by histamine H3 and H4 receptor activation.

  • Authors : Chan NY; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.; Robador PA

Subjects: Heart/Heart/Heart/*innervation ; Natriuretic Peptide, Brain/Natriuretic Peptide, Brain/Natriuretic Peptide, Brain/*pharmacology ; Neurons/Neurons/Neurons/*drug effects

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2012 Dec; Vol. 343 (3), pp. 568-77. Date Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium.

  • Authors : Vandeput F; Department of Internal Medicine (Cardiology), University of Utah School of Medicine, Salt Lake City, Utah, USA.; Krall J

Subjects: Cyclic AMP/Cyclic AMP/Cyclic AMP/*metabolism ; Heart Failure/Heart Failure/Heart Failure/*metabolism ; Myocardium/Myocardium/Myocardium/*metabolism

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2009 Sep; Vol. 330 (3), pp. 884-91. Date Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

  • Authors : Cheung YF; Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.; Kan Z

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism; 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors ; 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/genetics

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2007 Aug; Vol. 322 (2), pp. 600-9. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

A selective peroxisome proliferator-activated receptor gamma modulator with distinct fat cell regulation properties.

  • Authors : Fujimura T; Molecular Medicine Research Laboratories, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan. ; Kimura C

Subjects: Adipocytes/Adipocytes/Adipocytes/*drug effects ; Benzimidazoles/Benzimidazoles/Benzimidazoles/*pharmacology ; PPAR gamma/PPAR gamma/PPAR gamma/*drug effects

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2006 Aug; Vol. 318 (2), pp. 863-71. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one].

  • Authors : Boswell-Smith V; The Sackler Institute of Pulmonary Pharmacology, King's College London School of Biomedical and Health Sciences, Division of Pharmaceutical Sciences, London SE1 1UL, UK.; Spina D

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Phosphodiesterase Inhibitors/Phosphodiesterase Inhibitors/Phosphodiesterase Inhibitors/*pharmacology; Airway Resistance/Airway Resistance/Airway Resistance/drug effects

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2006 Aug; Vol. 318 (2), pp. 840-8. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.

  • Authors : Liu S; Merck Frosst Center for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Quebec H9R 4P8, Canada.; Veilleux A

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism ; Phosphodiesterase Inhibitors/Phosphodiesterase Inhibitors/Phosphodiesterase Inhibitors/*pharmacology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2005 Aug; Vol. 314 (2), pp. 846-54. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, on myocyte calcium cycling and contractility.

  • Authors : Jung AS; Department of Physiology, Temple University School of Medicine, 3420 N. Broad Street, Room 805 MRB, Philadelphia, PA 19140, USA.; Quaile MP

Subjects: Calcium/Calcium/Calcium/*metabolism ; Calcium Signaling/Calcium Signaling/Calcium Signaling/*drug effects ; Cardiotonic Agents/Cardiotonic Agents/Cardiotonic Agents/*pharmacology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2005 Feb; Vol. 312 (2), pp. 517-24. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition.

  • Authors : Chen YM; Department of Medicine, National Taiwan University Hospital, 7, Chung-Shan South Rd., Taipei, 10016, Taiwan.; Chiang WC

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Chemokine CCL2/Chemokine CCL2/Chemokine CCL2/*metabolism ; NF-kappa B/NF-kappa B/NF-kappa B/*physiology

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2004 Jun; Vol. 309 (3), pp. 978-86. Date Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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  • 1-10 of  16 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""