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Academic Journal

Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.

  • Authors : Goto A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.)

Subjects: Oligonucleotides* ; RNA*; Mice

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Jan; Vol. 384 (1), pp. 197-204. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury.

  • Authors : Taguchi K; Division of Pharmacodynamics, Faculty of Pharmacy, Keio University, Tokyo, Japan (K.T., Y.E., K.M.); Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences (K.T., M.O.) and DDS Research Institute (M.O.), Sojo University, Kumamoto, Japan

Subjects: Acute Kidney Injury/Acute Kidney Injury/Acute Kidney Injury/*drug therapy ; Carbon Monoxide/Carbon Monoxide/Carbon Monoxide/*therapeutic use ; Crush Syndrome/Crush Syndrome/Crush Syndrome/*complications

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Mar; Vol. 372 (3), pp. 355-365. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase.

  • Authors : Furukawa J; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya (J.F., T.Y., Y.M., H.Y.); College of Pharmacy, Kinjo Gakuin University, Nagoya (K.O.)

Subjects: Genetic Therapy*; Amino Acid Transport Systems/Amino Acid Transport Systems/Amino Acid Transport Systems/*metabolism ; Apoptosis/Apoptosis/Apoptosis/*genetics

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2017 Jan; Vol. 360 (1), pp. 59-68. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.

  • Authors : Maeda H; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences (H.M., K.H., H.W., Y.I., V.T.G.C., T.M.), Center for Clinical Pharmaceutical Sciences, School of Pharmacy (H.W., Y.I., T.M.), and Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences (M.T., Y.S.), Kumamoto University, Kumamoto, Japan; School of Pharmacy, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia (V.T.G.C.)

Subjects: Albumins/Albumins/Albumins/*therapeutic use ; Antigens, CD/Antigens, CD/Antigens, CD/*metabolism ; Antigens, Differentiation, Myelomonocytic/Antigens, Differentiation, Myelomonocytic/Antigens, Differentiation, Myelomonocytic/*metabolism

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2015 Feb; Vol. 352 (2), pp. 244-57. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines.

  • Authors : Nakashima T; Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.).

Subjects: Chemokines/Chemokines/Chemokines/*metabolism ; Cytokines/Cytokines/Cytokines/*metabolism ; Glossitis/Glossitis/Glossitis/*metabolism

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2013 Dec; Vol. 347 (3), pp. 660-8. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.

  • Authors : Tanaka R; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.; Watanabe H

Subjects: Pulmonary Fibrosis/Pulmonary Fibrosis/Pulmonary Fibrosis/*chemically induced ; Pulmonary Fibrosis/Pulmonary Fibrosis/Pulmonary Fibrosis/*drug therapy ; Serum Albumin/Serum Albumin/Serum Albumin/*therapeutic use

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2013 May; Vol. 345 (2), pp. 271-83. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Fluid resuscitation with hemoglobin vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model.

  • Authors : Taguchi K; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.; Ogaki S

Subjects: Disease Models, Animal*; Complement Activation/Complement Activation/Complement Activation/*physiology ; Escherichia coli/Escherichia coli/Escherichia coli/*growth & development

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Apr; Vol. 337 (1), pp. 201-8. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

  • Authors : Bains OS; Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Grigliatti TA

Subjects: Alcohol Oxidoreductases/Alcohol Oxidoreductases/Alcohol Oxidoreductases/*genetics ; Alcohol Oxidoreductases/Alcohol Oxidoreductases/Alcohol Oxidoreductases/*metabolism ; Daunorubicin/Daunorubicin/Daunorubicin/*metabolism

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Dec; Vol. 335 (3), pp. 533-45. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse.

  • Authors : Mason CW; Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA.; Hassan HE

Subjects: Central Nervous System Stimulants*; Benzamides/Benzamides/Benzamides/*therapeutic use ; Dopamine Agents/Dopamine Agents/Dopamine Agents/*therapeutic use

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Jun; Vol. 333 (3), pp. 854-64. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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Academic Journal

Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism.

  • Authors : Bains OS; Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3.; Karkling MJ

Subjects: Alcohol Oxidoreductases/Alcohol Oxidoreductases/Alcohol Oxidoreductases/*chemistry ; Antibiotics, Antineoplastic/Antibiotics, Antineoplastic/Antibiotics, Antineoplastic/*chemistry ; Daunorubicin/Daunorubicin/Daunorubicin/*chemistry

  • Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Mar; Vol. 332 (3), pp. 755-63. Date of Electronic Publication: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model:

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