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  • 1-10 of  145 results for ""Trypanosoma brucei brucei""

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Academic Journal

Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei .

  • Authors : Ferrins L; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.; Diaz R

Subjects: Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/drug effects ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 13985-14006. Date of Electronic Publication: 2024 Aug 13.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structure-Activity Study on Substituted, Core-Extended, and Dyad Naphthalene Diimide G-Quadruplex Ligands Leading to Potent Antitrypanosomal Agents.

  • Authors : Benassi A; Department of Chemistry, University of Pavia, 27100 Pavia, Italy.; Peñalver P

Subjects: G-Quadruplexes*/G-Quadruplexes*/G-Quadruplexes*/drug effects ; Naphthalenes*/Naphthalenes*/Naphthalenes*/pharmacology ; Naphthalenes*/Naphthalenes*/Naphthalenes*/chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10643-10654. Date of Electronic Publication: 2024 Jun 26.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Antitrypanosomal Chloronitrobenzamides.

  • Authors : Carrillo AK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.; Kadayat TM

Subjects: Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/drug therapy ; Trypanosoma brucei brucei* ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/toxicity

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3437-3447. Date of Electronic Publication: 2024 Feb 16.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

  • Authors : Zheng Y; Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, Amsterdam 1081 HZ, The Netherlands.; van den Kerkhof M

Subjects: Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/therapeutic use ; Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/drug therapy

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2849-2863. Date of Electronic Publication: 2024 Feb 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.

  • Authors : Linciano P; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.; Quotadamo A

Subjects: Trypanosoma cruzi* ; Trypanosoma brucei brucei* ; Leishmania infantum*

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 23; Vol. 66 (22), pp. 15230-15255. Date of Electronic Publication: 2023 Nov 03.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Synthesis and Biophysical and Biological Studies of N -Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites.

  • Authors : Nué-Martinez JJ; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.; PhD Programme in Medicinal Chemistry, Doctoral School, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.

Subjects: Antiprotozoal Agents*/Antiprotozoal Agents*/Antiprotozoal Agents*/chemistry ; Leishmania donovani*/Leishmania donovani*/Leishmania donovani*/metabolism ; Parasites*/Parasites*/Parasites*/drug effects

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Oct 12; Vol. 66 (19), pp. 13452-13480. Date of Electronic Publication: 2023 Sep 20.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose.

  • Authors : Racané L; Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia.; Ptiček L

Subjects: Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/drug therapy ; Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/parasitology ; Trypanosoma brucei brucei*

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 13043-13057. Date of Electronic Publication: 2023 Sep 18.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy.

  • Authors : Zheng Y; Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.; van den Kerkhof M

Subjects: Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/therapeutic use ; Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/drug therapy

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Aug 10; Vol. 66 (15), pp. 10252-10264. Date of Electronic Publication: 2023 Jul 20.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.

  • Authors : Cleghorn LAT; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.; Wall RJ

Subjects: Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/drug therapy ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/therapeutic use ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacokinetics

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Jul 13; Vol. 66 (13), pp. 8896-8916. Date of Electronic Publication: 2023 Jun 21.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery.

  • Authors : Singh B; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.; Sharma A

Subjects: Trypanosomiasis, African*/Trypanosomiasis, African*/Trypanosomiasis, African*/drug therapy ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/therapeutic use

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Feb 09; Vol. 66 (3), pp. 1972-1989. Date of Electronic Publication: 2023 Jan 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  145 results for ""Trypanosoma brucei brucei""