Search Results

Display Settings
Results per page: 10
Sort By: Relevance
Filter
  • 1-10 of  313 results for ""High-Throughput Screening Assays""

Your Filters

Publication : journal of medicinal chemistry
Reset filters
Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request
Academic Journal

Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1.

  • Authors : Yoon NG; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.; Choi D

Subjects: Fluorescent Dyes*/Fluorescent Dyes*/Fluorescent Dyes*/chemistry ; High-Throughput Screening Assays*/High-Throughput Screening Assays*/High-Throughput Screening Assays*/methods ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21421-21437. Date of Electronic Publication: 2024 Nov 20.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells.

  • Authors : Talele S; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California 92697, United States.; Gonzalez S

Subjects: RGS Proteins*/RGS Proteins*/RGS Proteins*/metabolism ; RGS Proteins*/RGS Proteins*/RGS Proteins*/genetics ; High-Throughput Screening Assays*/High-Throughput Screening Assays*/High-Throughput Screening Assays*/methods

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 28; Vol. 67 (22), pp. 20343-20352. Date of Electronic Publication: 2024 Nov 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy.

  • Authors : Suo Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

Subjects: Machine Learning* ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry ; Transcription Factors*/Transcription Factors*/Transcription Factors*/metabolism

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 18969-18980. Date of Electronic Publication: 2024 Oct 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

High-Throughput Screening of Antioxidant Drug Candidates from Natural Antioxidants with a "Zero" Intrinsic Fluorescence Peroxynitrite Sensing Precursor.

  • Authors : Zhang H; Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China.

Subjects: Peroxynitrous Acid*/Peroxynitrous Acid*/Peroxynitrous Acid*/analysis ; Antioxidants*/Antioxidants*/Antioxidants*/chemistry ; Antioxidants*/Antioxidants*/Antioxidants*/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17855-17865. Date of Electronic Publication: 2024 Sep 21.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

High-Throughput SFC-MS/MS Method to Measure EPSA and Predict Human Permeability.

  • Authors : Wang YT; Quantitative, Translational, and ADME Sciences (QTAS), AbbVie Inc., North Chicago, Illinois 60064, United States.; Price E

Subjects: High-Throughput Screening Assays*/High-Throughput Screening Assays*/High-Throughput Screening Assays*/methods ; Tandem Mass Spectrometry*/Tandem Mass Spectrometry*/Tandem Mass Spectrometry*/methods ; Permeability*

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 13765-13777. Date of Electronic Publication: 2024 Jul 08.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery.

  • Authors : Brocklehurst CE; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.; Altmann E

Subjects: Drug Discovery* ; High-Throughput Screening Assays*

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Feb 08; Vol. 67 (3), pp. 2118-2128. Date of Electronic Publication: 2024 Jan 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 .

  • Authors : Bothe U; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.; Günther J

Subjects: Interleukin-1 Receptor-Associated Kinases* ; High-Throughput Screening Assays* ; Indazoles*

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1225-1242. Date of Electronic Publication: 2024 Jan 16.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Fused Tetrahydroquinolines Are Interfering with Your Assay.

  • Authors : Bashore FM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Annor-Gyamfi J

Subjects: High-Throughput Screening Assays* ; Quinolines*/Quinolines*/Quinolines*/chemistry; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14434-14446. Date of Electronic Publication: 2023 Oct 24.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds.

  • Authors : Alves VM; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.; Yasgar A

Subjects: High-Throughput Screening Assays*/High-Throughput Screening Assays*/High-Throughput Screening Assays*/methods ; Artifacts*; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/chemistry

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 12828-12839. Date of Electronic Publication: 2023 Sep 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
Academic Journal

Design of Tracers in Fluorescence Polarization Assay for Extensive Application in Small Molecule Drug Discovery.

  • Authors : Hua L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Subjects: Drug Discovery* ; High-Throughput Screening Assays*; Ligands

  • Source: Journal of medicinal chemistry [J Med Chem] 2023 Aug 24; Vol. 66 (16), pp. 10934-10958. Date of Electronic Publication: 2023 Aug 10.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list
×
  • 1-10 of  313 results for ""High-Throughput Screening Assays""