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  • 1-9 of  9 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""

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Academic Journal

Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.

  • Authors : Rowley AM; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.; Yao G

Subjects: Heart* ; DNA*; Humans

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Feb 08; Vol. 67 (3), pp. 2049-2065. Date of Electronic Publication: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.

  • Authors : Roma G; Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV n. 3, I-16132 Genoa, Italy. ; Di Braccio M

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Coumarins/Coumarins/Coumarins/*chemical synthesis ; Morpholines/Morpholines/Morpholines/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2007 Jun 14; Vol. 50 (12), pp. 2886-95. Date of Electronic Publication: 2007 May 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Print

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Academic Journal

Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.

  • Authors : Van der Mey M; Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. ; Bommelé KM

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2003 May 08; Vol. 46 (10), pp. 2008-16.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Novel selective PDE4 inhibitors. 3. In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones.

  • Authors : Van der Mey M; Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1085c, 1081 HV Amsterdam, The Netherlands. ; Boss H

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2002 Jun 06; Vol. 45 (12), pp. 2520-5.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones.

  • Authors : Van der Mey M; Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. ; Hatzelmann A

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemical synthesis ; Phthalazines/Phthalazines/Phthalazines/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2001 Aug 02; Vol. 44 (16), pp. 2523-35.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.

  • Authors : Burnouf C; Pfizer Global Research & Development, Fresnes Laboratories, 3 à 9 rue de la Loge, 94265 Fresnes, France. ; Auclair E

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Anti-Asthmatic Agents/Anti-Asthmatic Agents/Anti-Asthmatic Agents/*chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2000 Dec 14; Vol. 43 (25), pp. 4850-67.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.

Subjects: Palladium*; 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors ; Anti-Asthmatic Agents/Anti-Asthmatic Agents/Anti-Asthmatic Agents/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 2000 Feb 24; Vol. 43 (4), pp. 675-82.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.

  • Authors : Crespo MI; Almirall Prodesfarma S.A., Research Center, Cardener 68-74, 08024 Barcelona, Spain.; Pagès L

Subjects: Drug Design*; 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Anti-Asthmatic Agents/Anti-Asthmatic Agents/Anti-Asthmatic Agents/*chemical synthesis

  • Source: Journal of medicinal chemistry [J Med Chem] 1998 Oct 08; Vol. 41 (21), pp. 4021-35.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies.

Subjects: Cardiotonic Agents/Cardiotonic Agents/Cardiotonic Agents/*chemistry ; Pyrimidines/Pyrimidines/Pyrimidines/*chemistry; 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/metabolism

  • Source: Journal of medicinal chemistry [J Med Chem] 1996 Sep 13; Vol. 39 (19), pp. 3671-83.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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  • 1-9 of  9 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""