Authors : Minegishi H; †Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.; ‡Department of Life Science, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.

Subjects: Structure-Activity Relationship*; Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/*methods ; Pyrazoles/Pyrazoles/Pyrazoles/*pharmacology

Source: Journal of medicinal chemistry [J Med Chem] 2015 May 28; Vol. 58 (10), pp. 4230-41. Date of Electronic Publication: 2015 May 11.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Read More Add to Saved list

Academic Journal

Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.

Authors : Greene, Thomas F.¹; Shu Wang¹; Greene, Lisa M.²

Subjects: *LACTAMS; *ANTINEOPLASTIC agents; *TUBULINS

Source: Journal of Medicinal Chemistry. Jan2016, Vol. 59 Issue 1, p90-113. 24p.

Record details

Read More Add to Saved list

Academic Journal

Design, Synthesis,and Biological Activity of SulfonamideAnalogues of Antofine and Cryptopleurine as Potent and Orally ActiveAntitumor Agents.

Authors : Yongseok Kwon¹; Jayoung Song¹; Honggu Lee¹

Subjects: *ANTINEOPLASTIC agents; *DRUG design; *CHEMICAL synthesis

Source: Journal of Medicinal Chemistry. Oct2015, Vol. 58 Issue 19, p7749-7762. 14p.

Record details

Read More Add to Saved list

Academic Journal

A Novel CovalentmTOR Inhibitor, DHM25, Shows in VivoAntitumor Activity against Triple-Negative Breast Cancer Cells.

Authors : Amélie Fouqué¹; Olivier Delalande¹; Mickael Jean¹

Subjects: *MTOR protein; *ANTINEOPLASTIC agents; *CARCINOGENESIS

Source: Journal of Medicinal Chemistry. Aug2015, Vol. 58 Issue 16, p6559-6573. 15p.

Record details

Read More Add to Saved list

Academic Journal

Synthesis, Characterization,and Optimization forin Vivo Delivery of a Nonselective Isopeptidase Inhibitor as New AntineoplasticAgent.

Authors : Cersosimo, Ulma¹; Sgorbissa, Andrea²; Foti, Carmen²

Subjects: *PEPTIDASE; *ANTINEOPLASTIC agents; *ENZYME inhibitors

Source: Journal of Medicinal Chemistry. Feb2015, Vol. 58 Issue 4, p1691-1704. 14p.

Record details

Read More Add to Saved list

Academic Journal

Design and Synthesis of PironetinAnalogue/ColchicineHybrids and Study of Their Cytotoxic Activity and Mechanisms of Interactionwith Tubulin.

Authors : Vilanova, Concepción¹; Díaz-Oltra, Santiago¹; Murga, Juan¹

Subjects: *COLCHICINE; *ANTINEOPLASTIC agents; *TUBULINS

Source: Journal of Medicinal Chemistry. Dec2014, Vol. 57 Issue 24, p10391-10403. 13p.

Record details

Read More Add to Saved list

Academic Journal

Hybrids of Phenylsulfonylfuroxanand Coumarin as PotentAntitumor Agents.

Authors : Liu, Ming-Ming¹; Chen, Xiao-Yu¹; Huang, Yao-Qing¹

Subjects: *THERAPEUTIC use of coumarins; *ANTINEOPLASTIC agents; *NITRIC oxide

Source: Journal of Medicinal Chemistry. Nov2014, Vol. 57 Issue 22, p9343-9356. 14p.

Record details

Read More Add to Saved list

Academic Journal

Synthesis and Structure–ActivityRelationshipStudies of N-Benzyl-2-phenylpyrimidin-4-amineDerivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with AnticancerActivity against Nonsmall Cell Lung Cancer.

Authors : Dexheimer, Thomas S.¹; Rosenthal, Andrew S.¹; Luci, Diane K.¹

Subjects: *LUNG cancer treatment; *ANTINEOPLASTIC agents; *CHEMICAL synthesis

Source: Journal of Medicinal Chemistry. Oct2014, Vol. 57 Issue 19, p8099-8110. 12p.

Record details

Read More Add to Saved list

Academic Journal

Discovery of (E)-3-((Styrylsulfonyl)methyl)pyridineand (E)-2-((Styrylsulfonyl)methyl)pyridineDerivatives as Anticancer Agents: Synthesis, Structure–ActivityRelationships, and Biological Activities.

Authors : Lu, Tiangong¹; Goh, Aik Wye¹; Yu, Mingfeng¹

Subjects: *PYRIDINE derivatives; *ANTINEOPLASTIC agents; *CHEMICAL synthesis

Source: Journal of Medicinal Chemistry. Mar2014, Vol. 57 Issue 6, p2275-2291. 17p.

Record details

Read More Add to Saved list

menu

Search Results

Your Filters

New Prospects for VinblastineAnalogues as Anticancer Agents.

Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.

Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.

Design, Synthesis,and Biological Activity of SulfonamideAnalogues of Antofine and Cryptopleurine as Potent and Orally ActiveAntitumor Agents.

A Novel CovalentmTOR Inhibitor, DHM25, Shows in VivoAntitumor Activity against Triple-Negative Breast Cancer Cells.

Synthesis, Characterization,and Optimization forin Vivo Delivery of a Nonselective Isopeptidase Inhibitor as New AntineoplasticAgent.

Design and Synthesis of PironetinAnalogue/ColchicineHybrids and Study of Their Cytotoxic Activity and Mechanisms of Interactionwith Tubulin.

Hybrids of Phenylsulfonylfuroxanand Coumarin as PotentAntitumor Agents.

Synthesis and Structure–ActivityRelationshipStudies of N-Benzyl-2-phenylpyrimidin-4-amineDerivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with AnticancerActivity against Nonsmall Cell Lung Cancer.

Discovery of (E)-3-((Styrylsulfonyl)methyl)pyridineand (E)-2-((Styrylsulfonyl)methyl)pyridineDerivatives as Anticancer Agents: Synthesis, Structure–ActivityRelationships, and Biological Activities.

Contact CCPL

Patron Login

menu

Search Results

Your Filters

Engage with CCPL

Contact CCPL