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Academic Journal

RNA Therapy for Oncogenic NRAS-Driven Nevi Induces Apoptosis.

  • Authors : Bryant D; Mosaicism and Precision Medicine Laboratory, The Francis Crick Institute, London, United Kingdom; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/genetics ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/genetics ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2025 Jan; Vol. 145 (1), pp. 122-134.e11. Date of Electronic Publication: 2024 Jun 17.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Vemurafenib Drives Epithelial-to-Mesenchymal Transition Gene Expression in BRAF Inhibitor‒Resistant BRAF V600E /NRAS Q61K Melanoma Enhancing Tumor Growth and Metastasis in a Bioluminescent Murine Model.

  • Authors : Jandova J; Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA; UA Cancer Center, The University of Arizona, Tucson, Arizona, USA.

Subjects: Melanoma*/Melanoma*/Melanoma*/drug therapy ; Melanoma*/Melanoma*/Melanoma*/genetics ; Melanoma*/Melanoma*/Melanoma*/pathology

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2022 May; Vol. 142 (5), pp. 1456-1465.e1. Date of Electronic Publication: 2021 Oct 21.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

MFN2 Stabilization: A Bridge for Endoplasmic Reticulum Stress Sensitivity in Melanoma.

  • Authors : Adelmann CH; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Rachmin I

Subjects: Endoplasmic Reticulum Stress* ; Melanoma*/Melanoma*/Melanoma*/metabolism; Endoplasmic Reticulum/Endoplasmic Reticulum/Endoplasmic Reticulum/metabolism

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2021 Dec; Vol. 141 (12), pp. 2782-2784. Date of Electronic Publication: 2021 Sep 23.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Molecular Context of Vulnerability for CDK9 Suppression in Triple Wild-Type Melanoma.

  • Authors : Guhan SM; Harvard Medical School, Boston, Massachusetts, USA; Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Subjects: Cyclin-Dependent Kinase 9/Cyclin-Dependent Kinase 9/Cyclin-Dependent Kinase 9/*antagonists & inhibitors ; Melanoma/Melanoma/Melanoma/*drug therapy ; Oxazoles/Oxazoles/Oxazoles/*pharmacology

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2021 Aug; Vol. 141 (8), pp. 2018-2027.e4. Date of Electronic Publication: 2021 Mar 18.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Report

The Distinctive Genomic Landscape of Giant Congenital Melanocytic Nevi.

  • Authors : Stark MS; The University of Queensland Diamantina Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Australia. Electronic address: .; Tell-Martí G

Subjects: Nevus, Pigmented/Nevus, Pigmented/Nevus, Pigmented/*genetics ; Skin Neoplasms/Skin Neoplasms/Skin Neoplasms/*genetics; Adolescent Melanocytic nevus syndrome, congenital

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2021 Mar; Vol. 141 (3), pp. 692-695.e2. Date of Electronic Publication: 2020 Aug 13.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Efficient Suppression of NRAS-Driven Melanoma by Co-Inhibition of ERK1/2 and ERK5 MAPK Pathways.

  • Authors : Adam C; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.; Fusi L

Subjects: Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology ; MAP Kinase Signaling System/MAP Kinase Signaling System/MAP Kinase Signaling System/*drug effects ; Melanoma/Melanoma/Melanoma/*drug therapy

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2020 Dec; Vol. 140 (12), pp. 2455-2465.e10. Date of Electronic Publication: 2020 May 04.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition.

  • Authors : Nguyen MQ; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Teh JLF

Subjects: Mutation*; GTP Phosphohydrolases/GTP Phosphohydrolases/GTP Phosphohydrolases/*genetics ; Glutathione/Glutathione/Glutathione/*metabolism

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2020 Nov; Vol. 140 (11), pp. 2242-2252.e7. Date of Electronic Publication: 2020 May 07.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Integrating Next-Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms.

  • Authors : Quan VL; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Zhang B

Subjects: High-Throughput Nucleotide Sequencing*; Melanoma/Melanoma/Melanoma/*diagnosis ; Neoplasm Recurrence, Local/Neoplasm Recurrence, Local/Neoplasm Recurrence, Local/*epidemiology

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2020 Aug; Vol. 140 (8), pp. 1599-1608. Date of Electronic Publication: 2020 Jan 29.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

TERT, BRAF, and NRAS Mutational Heterogeneity between Paired Primary and Metastatic Melanoma Tumors.

  • Authors : Chang GA; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, NYU Langone Health, New York, USA; The Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, NYU Langone Health, New York, USA

Subjects: GTP Phosphohydrolases/GTP Phosphohydrolases/GTP Phosphohydrolases/*genetics ; Melanoma/Melanoma/Melanoma/*genetics ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*genetics

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2020 Aug; Vol. 140 (8), pp. 1609-1618.e7. Date of Electronic Publication: 2020 Feb 20.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Data Independent Acquisition Proteomic Analysis Can Discriminate between Actinic Keratosis, Bowen's Disease, and Cutaneous Squamous Cell Carcinoma.

  • Authors : Azimi A; Center for Translational Skin Research, The University of Sydney, Westmead, New South Wales, Australia; Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.

Subjects: Biomarkers/Biomarkers/Biomarkers/*metabolism ; Bowen's Disease/Bowen's Disease/Bowen's Disease/*metabolism ; Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*metabolism

  • Source: The Journal of investigative dermatology [J Invest Dermatol] 2020 Jan; Vol. 140 (1), pp. 212-222.e11. Date of Electronic Publication: 2019 Jun 27.Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  37 results for ""GTP Phosphohydrolases genetics""