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Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.

• Authors : Ishii K; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, and.

Subjects: Immunotherapy, Adoptive/Immunotherapy, Adoptive/Immunotherapy, Adoptive/*adverse effects ; Perforin/Perforin/Perforin/*deficiency ; Receptors, Chimeric Antigen/Receptors, Chimeric Antigen/Receptors, Chimeric Antigen/*immunology

• Source: The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5425-5443.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium:

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Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.

Subjects: T cells; CYTOKINE release syndrome; CHIMERIC antigen receptors

• Source: Journal of Clinical Investigation. Oct2020, Vol. 130 Issue 10, p5425-5443. 19p.

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Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.

• Authors : Risma, Kimberly A.; Frayer, Robert W.; Filipovich, Alexandra H.

Subjects: GENETIC mutation; LYMPHOCYTES; MICROBIAL genetics

• Source: Journal of Clinical Investigation. Jan2006, Vol. 116 Issue 1, p182-192. 11p. 5 Black and White Photographs, 1 Diagram, 3 Charts, 4 Graphs.

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Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling.

• Authors : Otsuka, Shizuka¹; Melis, Nicolas²; Gaida, Matthias M.³

Subjects: *PERFORINS; *T cell receptors; *GRAFT versus host disease

• Source: Journal of Clinical Investigation. 6/1/2021, Vol. 131 Issue 11, p1-15. 15p.

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Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas.

• Authors : Curcio, Claudia; Di Carlo, Emma; Clynes, Raphael

Subjects: ONCOGENES; CANCER; VACCINATION

• Source: Journal of Clinical Investigation. 4/15/2003, Vol. 111 Issue 8, p1161. 10p. 2 Color Photographs, 3 Charts, 2 Graphs.

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Extracellular traps released by antimicrobial TH17 cells contribute to host defense.

• Authors : Agak, George W.; Mouton, Alice; Teles, Rosane M. B.

Subjects: T helper cells; T cells; NUCLEOTIDE sequence

• Source: Journal of Clinical Investigation. 1/15/2021, Vol. 131 Issue 2, p1-14. 14p. 2 Color Photographs, 1 Black and White Photograph, 1 Diagram, 4 Graphs.

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MicroRNA-29b mediates altered innate immune development in acute leukemia.

• Authors : Mundy-Bosse, Bethany L.; Scoville, Steven D.; Li Chen

Subjects: ACUTE leukemia; MICRORNA; KILLER cells

• Source: Journal of Clinical Investigation. Dec2016, Vol. 126 Issue 12, p4404-4416. 13p. 7 Graphs.

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TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.

• Authors : Lewis, Gavin M.; Wehrens, Ellen J.; Labarta-Bajo, Lara

Subjects: VIRUS diseases; T cells; ANTIVIRAL agents

• Source: Journal of Clinical Investigation. Oct2016, Vol. 126 Issue 10, p3799-3813. 15p. 7 Graphs.

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Immunosurveillance and therapy of multiple myeloma are CD226 dependent.

• Authors : Guillerey, Camille (AUTHOR); Ferrari de Andrade, Lucas (AUTHOR); Vuckovic, Slavica (AUTHOR)

• Source: Journal of Clinical Investigation. May2015, Vol. 125 Issue 5, p2077-2089. 13p.

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Immunosurveillance and therapy of multiple myeloma areCD226 dependent.

• Authors : Guillerey, Camille; Ferrari de Andrade, Lucas; Vuckovic, Slavica

Subjects: MULTIPLE myeloma; STROMAL cells; CYCLOPHOSPHAMIDE

• Source: Journal of Clinical Investigation. May2015, Vol. 125 Issue 5, p2077-2089. 13p. 7 Graphs.

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