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Academic Journal

Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2.

  • Authors : Dutta R; Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA.; Stanford School of Medicine, Stanford, California, USA.

Subjects: Aminopyridines/Aminopyridines/Aminopyridines/*pharmacology ; Cell Differentiation/Cell Differentiation/Cell Differentiation/*drug effects ; Erythroid Cells/Erythroid Cells/Erythroid Cells/*enzymology

  • Source: The Journal of clinical investigation [J Clin Invest] 2020 Apr 01; Vol. 130 (4), pp. 1843-1849.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium:

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Academic Journal

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.

  • Authors : De Souza DP; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.; Achuthan A

Subjects: Interferon Type I/Interferon Type I/Interferon Type I/*metabolism ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*antagonists & inhibitors ; Macrophages/Macrophages/Macrophages/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2019 Oct 01; Vol. 129 (10), pp. 4239-4244.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium:

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Academic Journal

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.

Subjects: Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*genetics ; CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*enzymology ; Glioma/Glioma/Glioma/*genetics

  • Source: The Journal of clinical investigation [J Clin Invest] 2017 Apr 03; Vol. 127 (4), pp. 1425-1437. Date of Electronic Publication: 2017 Mar 20.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Academic Journal

Isocitrate dehydrogenase mutations in leukemia.

  • Authors : McKenney AS; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.; Levine RL

Subjects: Mutation, Missense*; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*genetics ; Leukemia/Leukemia/Leukemia/*genetics

  • Source: The Journal of clinical investigation [J Clin Invest] 2013 Sep; Vol. 123 (9), pp. 3672-7. Date of Electronic Publication: 2013 Sep 03.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Academic Journal

Proximity ligation assay evaluates IDH1R132H presentation in gliomas.

Subjects: Antigen Presentation* ; Mutation, Missense*; Antigen-Presenting Cells/Antigen-Presenting Cells/Antigen-Presenting Cells/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2015 Feb; Vol. 125 (2), pp. 593-606. Date of Electronic Publication: 2015 Jan 02.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Academic Journal

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

  • Authors : McKenney AS; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York, USA.; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and.

Subjects: Gene Expression Regulation, Neoplastic*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*genetics

  • Source: The Journal of clinical investigation [J Clin Invest] 2018 Feb 01; Vol. 128 (2), pp. 789-804. Date of Electronic Publication: 2018 Jan 22.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Academic Journal

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.

  • Authors : Andronesi OC; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. ; Rapalino O

Subjects: Biomarkers, Tumor/Biomarkers, Tumor/Biomarkers, Tumor/*metabolism ; Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*metabolism ; Glioma/Glioma/Glioma/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2013 Sep; Vol. 123 (9), pp. 3659-63. Date of Electronic Publication: 2013 Sep 03.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Academic Journal

Postoperative risk of IDH-mutant glioma--associated seizures and their potential management with IDH-mutant inhibitors.

Subjects: *GLIOMAS; *ISOCITRATE dehydrogenase; *SEIZURES (Medicine)

  • Source: Journal of Clinical Investigation. 6/15/2023, Vol. 133 Issue 12, p1-14. 14p.

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Academic Journal

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice.

Subjects: *GLIOMAS; *ISOCITRATE dehydrogenase; *GAIN-of-function mutations

  • Source: Journal of Clinical Investigation. 2/15/2021, Vol. 131 Issue 4, p1-20. 20p.

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Academic Journal

Impact of epigenetic reprogramming on antitumor immune responses in glioma.

Subjects: GLIOMAS; EPIGENETICS; IMMUNE response

  • Source: Journal of Clinical Investigation. 1/17/2023, Vol. 133 Issue 2, p1-12. 13p.

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  • 1-10 of  251 results for ""ISOCITRATE dehydrogenase""