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Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.

• Authors : Marsan, Elise^1,2 ; Velmeshev, Dmitry^3,4; Ramsey, Arren¹

Subjects: *FRONTOTEMPORAL dementia; *FRONTOTEMPORAL lobar degeneration; *GLUTAMATE transporters

• Source: Journal of Clinical Investigation. 3/15/2023, Vol. 133 Issue 6, p1-18. 18p.

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Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function.

• Authors : Wu, Qianyi; Akhter, Azman; Pant, Shashank

• Source: Journal of Clinical Investigation. April 1, 2022, Vol. 132 Issue 7.

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15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.

• Authors : Tadao Nagasaki^1,2; Schuyler, Alexander J.²; Jinming Zhao^2,3

Subjects: *GLUTAMATE transporters; *GLUTATHIONE; *OXIDATION-reduction reaction

• Source: Journal of Clinical Investigation. Jan2022, Vol. 132 Issue 1, p1-12. 13p.

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Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

• Authors : Lu-Lin Jiang¹; Bing Zhu¹; Yingjun Zhao¹

Subjects: *MOTOR neurons; *SPINAL cord diseases; *AMYOTROPHIC lateral sclerosis

• Source: Journal of Clinical Investigation. Aug2019, Vol. 129 Issue 8, p3103-3120. 18p.

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Translational enhancers of EAAT2: therapeutic implications for neurodegenerative disease.

• Authors : Limpert AS; Cosford ND

Subjects: Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/*genetics ; Neuroprotective Agents/Neuroprotective Agents/Neuroprotective Agents/*pharmacology ; Protein Biosynthesis/Protein Biosynthesis/Protein Biosynthesis/*drug effects

• Source: The Journal of clinical investigation [J Clin Invest] 2014 Mar; Vol. 124 (3), pp. 964-7. Date of Electronic Publication: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.

• Authors : Kong Q; Chang LC; Takahashi K

Subjects: Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/*genetics ; Neuroprotective Agents/Neuroprotective Agents/Neuroprotective Agents/*pharmacology ; Protein Biosynthesis/Protein Biosynthesis/Protein Biosynthesis/*drug effects

• Source: The Journal of clinical investigation [J Clin Invest] 2014 Mar; Vol. 124 (3), pp. 1255-67. Date of Electronic Publication:Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.

• Authors : Qiongman Kong¹; Ling-Chu Chang¹; Kou Takahashi¹

Subjects: *GLUTAMATE transporters; *SMALL molecules; *NEURODEGENERATION

• Source: Journal of Clinical Investigation. Mar2014, Vol. 124 Issue 3, p1255-1267. 13p. 1 Black and White Photograph, 1 Chart, 4

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Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria.

• Authors : Bailey CG; Gene and Stem Cell Therapy Program, Centenary Institute, Camperdown, New South Wales, Australia.; Ryan RM

Subjects: Mutation*; Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/*genetics; Amino Acid Sequence Dicarboxylicaminoaciduria

• Source: The Journal of clinical investigation [J Clin Invest] 2011 Jan; Vol. 121 (1), pp. 446-53. Date of Electronic Publication: 2010 Dec 01.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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