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Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.

• Authors : Zeng L; From the Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, and.; Hu C

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Apoptosis/Apoptosis/Apoptosis/*genetics

• Source: The Journal of biological chemistry [J Biol Chem] 2015 Jul 24; Vol. 290 (30), pp. 18269-80. Date of Electronic Publication: 2015 May 29.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.

• Authors : Yamamoto-Tanaka M; From the Shiseido Innovative Science Research Center, 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama 224-8558, the Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, and.; Motoyama A

Subjects: Caspases/Caspases/Caspases/*metabolism ; Saposins/Saposins/Saposins/*metabolism ; Skin/Skin/Skin/*metabolism

• Source: The Journal of biological chemistry [J Biol Chem] 2014 Jul 18; Vol. 289 (29), pp. 20026-38. Date of Electronic Publication: 2014 May 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Saposin A mobilizes lipids from low cholesterol and high bis(monoacylglycerol)phosphate-containing membranes: patient variant Saposin A lacks lipid extraction capacity.

• Authors : Locatelli-Hoops S; Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.; Remmel N

Subjects: Genetic Variation* ; Lipid Metabolism*; Cholesterol/Cholesterol/Cholesterol/*chemistry

• Source: The Journal of biological chemistry [J Biol Chem] 2006 Oct 27; Vol. 281 (43), pp. 32451-60. Date of Electronic Publication: 2006 Aug 12.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux.

• Authors : Kiss RS; Lipoprotein and Atherosclerosis Research Group, Department of Pathology and Laboratory Medicine, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada.; Ma Z

Subjects: Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Cholesterol/Cholesterol/Cholesterol/*metabolism ; Endosomes/Endosomes/Endosomes/*metabolism

• Source: The Journal of biological chemistry [J Biol Chem] 2006 Apr 28; Vol. 281 (17), pp. 12081-92. Date of Electronic Publication: 2006 Feb 22.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.

• Authors : Ell B; From the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544.; Qiu Q

Subjects: Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*genetics ; Lung Neoplasms/Lung Neoplasms/Lung Neoplasms/*genetics ; Lung Neoplasms/Lung Neoplasms/Lung Neoplasms/*secondary

• Source: The Journal of biological chemistry [J Biol Chem] 2014 Aug 08; Vol. 289 (32), pp. 21888-95. Date of Electronic Publication: 2014 Jun 25.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability.

• Authors : Lundius EG; From the Laboratory of Translational Neuropharmacology and.; Vukojevic V

Subjects: Cell Membrane/Cell Membrane/Cell Membrane/*metabolism ; G(M1) Ganglioside/G(M1) Ganglioside/G(M1) Ganglioside/*metabolism ; Receptors, G-Protein-Coupled/Receptors, G-Protein-Coupled/Receptors, G-Protein-Coupled/*metabolism

• Source: The Journal of biological chemistry [J Biol Chem] 2014 Feb 21; Vol. 289 (8), pp. 4660-73. Date of Electronic Publication: 2013 Dec 26.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.

• Authors : Matzner U; Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-University, 53115 Bonn, Germany. ; Breiden B

Subjects: Models, Biological*; Cerebroside-Sulfatase/Cerebroside-Sulfatase/Cerebroside-Sulfatase/*metabolism ; Leukodystrophy, Metachromatic/Leukodystrophy, Metachromatic/Leukodystrophy, Metachromatic/*enzymology

• Source: The Journal of biological chemistry [J Biol Chem] 2009 Apr 03; Vol. 284 (14), pp. 9372-81. Date of Electronic Publication: 2009 Feb 18.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Differential Membrane Interactions of Saposins A and C

• Authors : Qi, Xiaoyang; Grabowski, Gregory A.

• Source: Journal of Biological Chemistry; July 2001, Vol. 276 Issue: 29 p27010-27017, 8p

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Effect of saposins A and C on the enzymatic hydrolysis of liposomal glucosylceramide.

• Authors : Vaccaro, A M; Tatti, M; Ciaffoni, F

• Source: Journal of Biological Chemistry; July 1997, Vol. 272 Issue: 27 p16862-7, 6p

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pH-dependent Conformational Properties of Saposins and Their Interactions with Phospholipid Membranes (∗)

• Authors : Vaccaro, Anna Maria; Ciaffoni, Fiorella; Tatti, Massimo

• Source: Journal of Biological Chemistry; December 1995, Vol. 270 Issue: 51 p30576-30580, 5p

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