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Academic Journal

Structure of phosphorylated-like RssB, the adaptor delivering σ s to the ClpXP proteolytic machinery, reveals an interface switch for activation.

  • Authors : Brugger C; Laboratories of Molecular Medicine, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.; Schwartz J

Subjects: DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/chemistry ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/metabolism ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/chemistry

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105440. Date of Electronic Publication: 2023 Nov 09.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis.

  • Authors : Azadmanesh J; The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.; Seleem MA

Subjects: Chlamydia trachomatis*/Chlamydia trachomatis*/Chlamydia trachomatis*/enzymology ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/chemistry ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102762. Date of Electronic Publication: 2022 Dec 01.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA+ ATPase function.

  • Authors : Wang X; Laboratory of Cellular Biophysics, The Rockefeller University, New York, New York, USA.; Simon SM

Subjects: Adenosine Triphosphatases*/Adenosine Triphosphatases*/Adenosine Triphosphatases*/genetics ; Adenosine Triphosphatases*/Adenosine Triphosphatases*/Adenosine Triphosphatases*/metabolism ; ATPases Associated with Diverse Cellular Activities*/ATPases Associated with Diverse Cellular Activities*/ATPases Associated with Diverse Cellular Activities*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2022 Oct; Vol. 298 (10), pp. 102457. Date of Electronic Publication: 2022 Sep 05.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease.

  • Authors : Taylor G; ETH Zurich, Institute of Molecular Biology and Biophysics, Zurich, Switzerland.; Frommherz Y

Subjects: Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/enzymology ; Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/metabolism; Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/*pharmacology

  • Source: The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102202. Date of Electronic Publication: 2022 Jun 26.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules.

  • Authors : Mabanglo MF; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Houry WA

Subjects: Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/chemistry ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/genetics ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/ultrastructure

  • Source: The Journal of biological chemistry [J Biol Chem] 2022 May; Vol. 298 (5), pp. 101781. Date of Electronic Publication: 2022 Mar 02.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Degradation of the E. coli antitoxin MqsA by the proteolytic complex ClpXP is regulated by zinc occupancy and oxidation.

  • Authors : Vos MR; Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA; Graduate Program in Molecular Biology and Biochemistry, University of Connecticut Health Center, Farmington, Connecticut, USA.

Subjects: Antitoxins*/Antitoxins*/Antitoxins*/metabolism ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/metabolism ; Endopeptidase Clp*/Endopeptidase Clp*/Endopeptidase Clp*/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2022 Feb; Vol. 298 (2), pp. 101557. Date of Electronic Publication: 2021 Dec 30.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease.

  • Authors : Zuromski KL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Kim S

Subjects: Protein Multimerization*; Endopeptidase Clp/Endopeptidase Clp/Endopeptidase Clp/*chemistry ; Escherichia coli/Escherichia coli/Escherichia coli/*enzymology

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101407. Date of Electronic Publication: 2021 Nov 12.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.

  • Authors : Rondelli CM; Department of Biological Sciences, University of Delaware, Newark, Delaware, USA.; Perfetto M

Subjects: 5-Aminolevulinate Synthetase/5-Aminolevulinate Synthetase/5-Aminolevulinate Synthetase/*metabolism ; Endopeptidase Clp/Endopeptidase Clp/Endopeptidase Clp/*metabolism ; Ferrochelatase/Ferrochelatase/Ferrochelatase/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Aug; Vol. 297 (2), pp. 100972. Date of Electronic Publication: 2021 Jul 16.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Degradation of MinD oscillator complexes by Escherichia coli ClpXP.

  • Authors : LaBreck CJ; Department of Cell & Molecular Biology, The University of Rhode Island, Kingston, Rhode Island, USA.; Trebino CE

Subjects: ATPases Associated with Diverse Cellular Activities/ATPases Associated with Diverse Cellular Activities/ATPases Associated with Diverse Cellular Activities/*chemistry ; Adenosine Triphosphate/Adenosine Triphosphate/Adenosine Triphosphate/*chemistry ; Endopeptidase Clp/Endopeptidase Clp/Endopeptidase Clp/*chemistry

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100162. Date of Electronic Publication: 2020 Dec 10.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis.

  • Authors : Bouchnak I; Section of Plant Biology, School of Integrative Plant Sciences (SIPS), Cornell University, Ithaca, New York, USA.; van Wijk KJ

Subjects: Apicoplasts/Apicoplasts/Apicoplasts/*enzymology ; Cyanobacteria/Cyanobacteria/Cyanobacteria/*enzymology ; Endopeptidase Clp/Endopeptidase Clp/Endopeptidase Clp/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100338. Date of Electronic Publication: 2021 Jan 23.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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