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Academic Journal

Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A.

  • Authors : Zemskov EA; Center for Translational Science, Florida International University, Port St Lucie, Florida, USA; Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Oct; Vol. 300 (10), pp. 107723. Date of Electronic Publication: 2024 Aug 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury.

  • Authors : Zemskov EA; Department of Medicine, The University of Arizona Health Sciences, Tucson, Arizona, USA.; Wu X

Subjects: Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/metabolism ; Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/genetics ; Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/pathology

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Aug; Vol. 297 (2), pp. 100946. Date of Electronic Publication: 2021 Jul 10.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.

  • Authors : Wu X; Cancer Program, Broad Institute, Cambridge, Massachusetts 02142.; Schnitzler GR

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism ; Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/*metabolism ; Neoplasms/Neoplasms/Neoplasms/*pathology

  • Source: The Journal of biological chemistry [J Biol Chem] 2020 Mar 13; Vol. 295 (11), pp. 3431-3446. Date of Electronic Publication: 2020 Jan 31.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity.

  • Authors : Gorelik A; From the Department of Biochemistry and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, Quebec H3G 0B1, Canada.; Heinz LX

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*chemistry; Adenosine Diphosphate/Adenosine Diphosphate/Adenosine Diphosphate/chemistry ; Adenosine Diphosphate/Adenosine Diphosphate/Adenosine Diphosphate/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2016 Nov 11; Vol. 291 (46), pp. 24054-24064. Date of Electronic Publication: 2016 Sep 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.

  • Authors : Ahmad F; From the Cardiovascular Pulmonary Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, .; Shen W

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism ; Myocardium/Myocardium/Myocardium/*metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/Sarcoplasmic Reticulum Calcium-Transporting ATPases/Sarcoplasmic Reticulum Calcium-Transporting ATPases/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2015 Mar 13; Vol. 290 (11), pp. 6763-76. Date of Electronic Publication: 2015 Jan 15.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.

  • Authors : Suk HY; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.; Zhou C

Subjects: Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects; Calcineurin/Calcineurin/Calcineurin/*deficiency ; Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2013 Feb 01; Vol. 288 (5), pp. 3477-88. Date of Electronic Publication: 2012 Dec 20.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.

  • Authors : Bruss MD; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143, USA.; Richter W

Subjects: Cyclic AMP/Cyclic AMP/Cyclic AMP/*physiology ; Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/Cyclic Nucleotide Phosphodiesterases, Type 4/Cyclic Nucleotide Phosphodiesterases, Type 4/*genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2008 Aug 15; Vol. 283 (33), pp. 22430-42. Date of Electronic Publication: 2008 May 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.

  • Authors : Begum N; Cardiovascular-Pulmonary Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. ; Hockman S

Subjects: Gene Deletion*; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*deficiency

  • Source: The Journal of biological chemistry [J Biol Chem] 2011 Jul 22; Vol. 286 (29), pp. 26238-49. Date of Electronic Publication: 2011 Jun 01.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.

  • Authors : Wilson LS; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.; Baillie GS

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/Cyclic Nucleotide Phosphodiesterases, Type 3/*metabolism ; Endothelial Cells/Endothelial Cells/Endothelial Cells/*metabolism ; Guanine Nucleotide Exchange Factors/Guanine Nucleotide Exchange Factors/Guanine Nucleotide Exchange Factors/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2011 May 06; Vol. 286 (18), pp. 16285-96. Date of Electronic Publication: 2011 Mar 10.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.

  • Authors : Rampersad SN; Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario K7L 3N6, Canada.; Ovens JD

Subjects: Antigens, CD/Antigens, CD/Antigens, CD/*metabolism ; Cadherins/Cadherins/Cadherins/*metabolism ; Cyclic AMP/Cyclic AMP/Cyclic AMP/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2010 Oct 29; Vol. 285 (44), pp. 33614-22. Date of Electronic Publication: 2010 Aug 23.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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  • 1-10 of  38 results for ""Cyclic Nucleotide Phosphodiesterases, Type 3""