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Academic Journal

Clinical Implications of Isocitrate Dehydrogenase Mutations and Targeted Treatment of Acute Myeloid Leukemia with Mutant Isocitrate Dehydrogenase Inhibitors-Recent Advances, Challenges and Future Prospects.

  • Authors : Kowalczyk A; Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.; Zarychta J

Subjects: Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/genetics ; Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/antagonists & inhibitors ; Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/drug therapy

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 19; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Molecular Targeting of the Isocitrate Dehydrogenase Pathway and the Implications for Cancer Therapy.

  • Authors : Ivanov S; Memorial Cancer Institute, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.; Nano O

Subjects: Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/genetics ; Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/antagonists & inhibitors ; Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 04; Vol. 25 (13). Date of Electronic Publication: 2024 Jul 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma.

  • Authors : Silva FFVE; Department of Medicine and Dentistry, University of Santiago de Compostela, San Francisco Street, s/n, 15782 Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.

Subjects: Glioblastoma*/Glioblastoma*/Glioblastoma*/genetics ; Guanine*/Guanine*/Guanine*/analogs & derivatives ; Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 03; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 03.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Discovery of Aloperine as a Potential Antineoplastic Agent for Cholangiocarcinoma Harboring Mutant IDH1.

  • Authors : Wu X; Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.; Li Y

Subjects: Cholangiocarcinoma*/Cholangiocarcinoma*/Cholangiocarcinoma*/drug therapy ; Cholangiocarcinoma*/Cholangiocarcinoma*/Cholangiocarcinoma*/genetics ; Cholangiocarcinoma*/Cholangiocarcinoma*/Cholangiocarcinoma*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 25; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

3D-QSAR, Scaffold Hopping, Virtual Screening, and Molecular Dynamics Simulations of Pyridin-2-one as mIDH1 Inhibitors.

  • Authors : Wang Y; College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave, Xi'an-Xianyang New Economic Zone, Xianyang 712046, China.; Jia S

Subjects: Quantitative Structure-Activity Relationship* ; Molecular Dynamics Simulation* ; Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/antagonists & inhibitors

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 06; Vol. 25 (13). Date of Electronic Publication: 2024 Jul 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Methylation-Based Characterization of a New IDH2 Mutation in Sinonasal Undifferentiated Carcinoma.

  • Authors : Burgermeister S; Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.; Stoykova S

Subjects: Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/genetics ; DNA Methylation*/DNA Methylation*/DNA Methylation*/genetics ; Carcinoma*/Carcinoma*/Carcinoma*/genetics Sinonasal undifferentiated carcinoma

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 13; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans .

  • Authors : Lin ZH; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.; Institute of Chemistry, Academia Sinica, Taipei 115201, Taiwan.

Subjects: Caenorhabditis elegans*/Caenorhabditis elegans*/Caenorhabditis elegans*/enzymology ; Caenorhabditis elegans*/Caenorhabditis elegans*/Caenorhabditis elegans*/genetics ; Caenorhabditis elegans Proteins*/Caenorhabditis elegans Proteins*/Caenorhabditis elegans Proteins*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 29; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Profiling the Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic Cells.

  • Authors : Shait Mohammed MR; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Centre of Artificial Intelligence for Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Subjects: Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/genetics ; Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/Isocitrate Dehydrogenase*/metabolism ; Leukemia*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 15; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Biochemical Characterization and Crystal Structure of a Novel NAD + -Dependent Isocitrate Dehydrogenase from Phaeodactylum tricornutum .

  • Authors : Huang SP; Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases and Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.; Zhou LC

Subjects: Diatoms/Diatoms/Diatoms/*enzymology ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*chemistry; Allosteric Regulation

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Aug 18; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Nanomechanical Signatures in Glioma Cells Depend on CD44 Distribution in IDH1 Wild-Type but Not in IDH1R132H Mutant Early-Passage Cultures.

  • Authors : Shmelev ME; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.; Farniev VM

Subjects: Glioma*/Glioma*/Glioma*/diagnosis ; Glioma*/Glioma*/Glioma*/metabolism ; Glioma*/Glioma*/Glioma*/pathology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 17; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 of  1,204 results for ""Isocitrate Dehydrogenase""