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Academic Journal

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules.

Subjects: DNA/DNA/DNA/*genetics ; Forkhead Box Protein O3/Forkhead Box Protein O3/Forkhead Box Protein O3/*genetics ; Promoter Regions, Genetic/Promoter Regions, Genetic/Promoter Regions, Genetic/*genetics

  • Source: ELife [Elife] 2019 Dec 04; Vol. 8. Date of Electronic Publication: 2019 Dec 04.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Therapeutic downregulation of neuronal PAS domain 2 ( Npas2 ) promotes surgical skin wound healing.

  • Authors : Shibuya Y; Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.; Weintraub Center for Reconstructive Biotechnology, Los Angeles, United States.

Subjects: Down-Regulation*; Basic Helix-Loop-Helix Transcription Factors/Basic Helix-Loop-Helix Transcription Factors/Basic Helix-Loop-Helix Transcription Factors/*genetics ; Nerve Tissue Proteins/Nerve Tissue Proteins/Nerve Tissue Proteins/*genetics

  • Source: ELife [Elife] 2022 Jan 18; Vol. 11. Date of Electronic Publication: 2022 Jan 18.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.

  • Authors : Livingston KE; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, United States.; Edward F Domino Research Center, University of Michigan, Ann Arbor, United States.

Subjects: Biosensing Techniques*; Interferometry/Interferometry/Interferometry/*methods ; Receptors, Opioid, mu/Receptors, Opioid, mu/Receptors, Opioid, mu/*analysis

  • Source: ELife [Elife] 2018 Jun 22; Vol. 7. Date of Electronic Publication: 2018 Jun 22.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.

  • Authors : Chen X; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, United Kingdom.; Bioinformatics Lab, School of Life Sciences, University of Sussex, Falmer, United Kingdom.

Subjects: RecQ Helicases/RecQ Helicases/RecQ Helicases/*antagonists & inhibitors ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*chemistry ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: ELife [Elife] 2021 Mar 01; Vol. 10. Date of Electronic Publication: 2021 Mar 01.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels.

  • Authors : Zhang H; Departments of Chemistry and Chemical Biology and Physics, Harvard University, Cambridge, United States.; Howard Hughes Medical Institute, Harvard University, Cambridge, United States.

Subjects: Action Potentials/Action Potentials/Action Potentials/*physiology ; Electrophysiology/Electrophysiology/Electrophysiology/*methods ; NAV1.7 Voltage-Gated Sodium Channel/NAV1.7 Voltage-Gated Sodium Channel/NAV1.7 Voltage-Gated Sodium Channel/*metabolism

  • Source: ELife [Elife] 2016 May 24; Vol. 5. Date of Electronic Publication: 2016 May 24.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Discovery of a small molecule that inhibits bacterial ribosome biogenesis.

  • Authors : Stokes JM; Michael G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Davis JH

Subjects: Escherichia coli/Escherichia coli/Escherichia coli/*metabolism ; Ribosomes/Ribosomes/Ribosomes/*metabolism ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*pharmacology

  • Source: ELife [Elife] 2014 Sep 18; Vol. 3, pp. e03574. Date of Electronic Publication: 2014 Sep 18.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

De novo design of a homo-trimeric amantadine-binding protein.

  • Authors : Park J; Department of Biochemistry, University of Washington, Seattle, United States.; Institute for Protein Design, University of Washington, Seattle, United States.

Subjects: Protein Engineering*; Amantadine/Amantadine/Amantadine/*chemistry ; Proteins/Proteins/Proteins/*chemistry

  • Source: ELife [Elife] 2019 Dec 19; Vol. 8. Date of Electronic Publication: 2019 Dec 19.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.

  • Authors : Torres SE; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.

Subjects: Unfolded Protein Response*/Unfolded Protein Response*/Unfolded Protein Response*/drug effects; Activating Transcription Factor 6/Activating Transcription Factor 6/Activating Transcription Factor 6/*antagonists & inhibitors ; Organelles/Organelles/Organelles/*metabolism

  • Source: ELife [Elife] 2019 May 31; Vol. 8. Date of Electronic Publication: 2019 May 31.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Expanding the olfactory code by in silico decoding of odor-receptor chemical space.

  • Authors : Boyle SM; Genetics, Genomics, and Bioinformatics Program , University of California, Riverside , Riverside , United States.; McInally S

Subjects: Drosophila Proteins/Drosophila Proteins/Drosophila Proteins/*chemistry ; Drosophila melanogaster/Drosophila melanogaster/Drosophila melanogaster/*physiology ; Odorants/Odorants/Odorants/*analysis

  • Source: ELife [Elife] 2013 Oct 01; Vol. 2, pp. e01120. Date of Electronic Publication: 2013 Oct 01.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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Academic Journal

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.

  • Authors : Paxman R; Department of Chemistry, The Scripps Research Institute, La Jolla, United States.; Plate L

Subjects: Activating Transcription Factor 6/Activating Transcription Factor 6/Activating Transcription Factor 6/*genetics ; Amides/Amides/Amides/*pharmacology ; Endoplasmic Reticulum Stress/Endoplasmic Reticulum Stress/Endoplasmic Reticulum Stress/*drug effects

  • Source: ELife [Elife] 2018 Aug 07; Vol. 7. Date of Electronic Publication: 2018 Aug 07.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic

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  • 1-10 of  44 results for ""Small Molecule Libraries""