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  • 1-10 of  77 results for ""Liver-Specific Organic Anion Transporter 1""
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Academic Journal

Molecular Mechanisms for the Selective Transport of Dichlorofluorescein by Human Organic Anion Transporting Polypeptide 1B1.

  • Authors : Liu H; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China (H.L., L.L., T.L., R.H., C.G.); and Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (B.H.).

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Oct 16; Vol. 52 (11), pp. 1323-1331. Date of Electronic Publication: 2024 Oct 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion-Transporting Polypeptide 1B-Mediated Clinical Drug-Drug Interactions.

  • Authors : Feng B; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., G.L., C.Z., S.L., H.H., J.W., H.G., S.K.) and PhoenixBio USA Corporation, New York, New York (Y.M.) .; Liang G

Subjects: Drug Interactions* ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/antagonists & inhibitors

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Sep 16; Vol. 52 (10), pp. 1073-1082. Date of Electronic Publication: 2024 Sep 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I.

  • Authors : Wang Z; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore

Subjects: Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Coproporphyrins*/Coproporphyrins*/Coproporphyrins*/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Oct 16; Vol. 52 (11), pp. 1356-1362. Date of Electronic Publication: 2024 Oct 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Mechanistic Account of Distinct Change in Organic Anion Transporting Polypeptide 1B (OATP1B) Substrate Pharmacokinetics during OATP1B-Mediated Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.

  • Authors : Hegde PV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.; Morse BL

Subjects: Drug Interactions*/Drug Interactions*/Drug Interactions*/physiology ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/metabolism ; Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/Liver-Specific Organic Anion Transporter 1*/genetics

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Jul 16; Vol. 52 (8), pp. 886-898. Date of Electronic Publication: 2024 Jul 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid.

  • Authors : Zhang Y; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India.

Subjects: Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/metabolism ; Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/Chenodeoxycholic Acid*/pharmacology ; Coproporphyrins*/Coproporphyrins*/Coproporphyrins*/blood

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Aug; Vol. 50 (8), pp. 1077-1086. Date of Electronic Publication: 2022 May 30.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models.

  • Authors : Sane R; Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.) .

Subjects: Models, Biological*; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism ; Rosuvastatin Calcium/Rosuvastatin Calcium/Rosuvastatin Calcium/*pharmacokinetics

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Dec; Vol. 48 (12), pp. 1264-1270. Date of Electronic Publication: 2020 Oct 09.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel.

  • Authors : Mori D; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan (D.M., T.M., Y.K., G.N., K.M., H.K.); Division of Medical Oncology, Department of Medicine (H.I., Y.S.), and Division of Respiratory Medicine and Allergology, Department of Medicine (S.K.), Showa University School of Medicine, Tokyo, Japan

Subjects: Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*drug therapy ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors ; Lung Neoplasms/Lung Neoplasms/Lung Neoplasms/*drug therapy

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 May; Vol. 48 (5), pp. 387-394. Date of Electronic Publication: 2020 Feb 29.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport.

  • Authors : Wagner JB; Ward Family Heart Center (J.B.W.) and Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation (J.B.W., J.S.L.), Children's Mercy, Kansas City, Missouri; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri (J.B.W., J.S.L.)

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism ; Pravastatin/Pravastatin/Pravastatin/*pharmacokinetics

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Nov; Vol. 48 (11), pp. 1192-1198. Date of Electronic Publication: 2020 Sep 05.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans.

  • Authors : Zhang Y; Departments of Metabolism and Pharmacokinetics (Y.Z., M.S., H.S.) and Bioanalytical Sciences (H.K., J.Z.), Bristol Myers Squibb Company, Princeton, New Jersey; and Departments of Metabolism and Pharmacokinetics (V.K.H., T.T.M.), Biocon Bristol Myers Squibb R&D Centre (BBRC), Syngene International Ltd., Biocon Park, Bommasandra IV Phase, Bangalore, India.

Subjects: Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors ; Probenecid/Probenecid/Probenecid/*pharmacology ; Solute Carrier Organic Anion Transporter Family Member 1B3/Solute Carrier Organic Anion Transporter Family Member 1B3/Solute Carrier Organic Anion Transporter Family Member 1B3/*antagonists & inhibitors

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Oct; Vol. 48 (10), pp. 841-848. Date of Electronic Publication: 2020 Jul 28.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Static Model-Based Assessment of OATP1B1-Mediated Drug Interactions with Preincubation-Dependent Inhibitors Based on Inactivation and Recovery Kinetics.

  • Authors : Taguchi T; Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan (T.T.) and Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (T.T., Y.M., A.F., Y.K.).; Masuo Y

Subjects: Drug Interactions* ; Models, Biological*; Hepatobiliary Elimination/Hepatobiliary Elimination/Hepatobiliary Elimination/*physiology

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Sep; Vol. 48 (9), pp. 750-758. Date of Electronic Publication: 2020 Jul 02.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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  • 1-10 of  77 results for ""Liver-Specific Organic Anion Transporter 1""