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Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.

• Authors : Geven C; Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, HP: 710, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.; van Lier D

Subjects: Adrenomedullin/Adrenomedullin/Adrenomedullin/*antagonists & inhibitors ; Antibodies, Monoclonal, Humanized/Antibodies, Monoclonal, Humanized/Antibodies, Monoclonal, Humanized/*administration & dosage ; Endotoxemia/Endotoxemia/Endotoxemia/*drug therapy

• Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2018 Sep; Vol. 84 (9), pp. 2129-2141. Date of Electronic Publication: 2018 Jul 03.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Increased concentrations of bioactive adrenomedullin subsequently to angiotensin‐receptor/neprilysin‐inhibitor treatment in chronic systolic heart failure.

• Authors : Arfsten, Henrike; Goliasch, Georg; Bartko, Philipp E.

Subjects: NEPRILYSIN; ADRENOMEDULLIN; HEART failure

• Source: British Journal of Clinical Pharmacology; Mar2021, Vol. 87 Issue 3, p916-924, 9p

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Effects of adrenomedullin on angiotensin II stimulated atrial natriuretic peptide and arginine vasopressin secretion in healthy humans.

• Authors : Petrie, Mark C.¹; McDonald, John E.¹; Hillier, Chris²

Subjects: *ADRENOMEDULLIN; *ATRIAL natriuretic peptides; *VASOPRESSIN

• Source: British Journal of Clinical Pharmacology. Aug2001, Vol. 52 Issue 2, p165-168. 4p. 1 Diagram, 2 Graphs.

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Proadrenomedullin N-terminal 20 peptide (PAMP) causes vasodilatation in the human forearm vascular bed but is less potent than adrenomedullin (ADM).

• Authors : McEniery, C.M.; Wilkinson, I.B.; Webb, D.J.

Subjects: *ADRENOMEDULLIN; *PEPTIDE hormones; *CARDIOVASCULAR agents

• Source: British Journal of Clinical Pharmacology. Dec99, Vol. 48 Issue 6, p873P. 2p.

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Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP).

• Authors : Wilkinson, Ian B.; McEniery, Carmel M.; Bongaerts, Katherine H.

Subjects: ADRENOMEDULLIN; FOREARM; ENDOPEPTIDASES

• Source: British Journal of Clinical Pharmacology; Aug2001, Vol. 52 Issue 2, p159-164, 6p, 2 Graphs

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Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels.

• Authors : Cockcroft, John R.; Noon, Joseph P.; Gardner-Medwin, Janet

• Source: British Journal of Clinical Pharmacology; Jul1997, Vol. 44 Issue 1, p57-60, 4p

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Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions.

• Authors : Pintér, Erika; Pozsgai, Gábor; Hajna, Zsófia

Subjects: NEUROPEPTIDES; IMMUNE system; CYTOKINES

• Source: British Journal of Clinical Pharmacology; Jan2014, Vol. 77 Issue 1, p5-20, 16p

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The regulation of pulmonary vascular tone.

• Authors : WILKINS, MARTIN R.; AL-TUBULY, RIDA

• Source: British Journal of Clinical Pharmacology; Jul1996, Vol. 42 Issue 1, p127-131, 5p

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Issue highlights.

Subjects: CLINICAL trials; GENOTYPES; DRUG dosage

• Source: British Journal of Clinical Pharmacology; Sep2018, Vol. 84 Issue 9, p1863-1864, 2p

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Development of anti-migraine therapeutics using the capsaicin-induced dermal blood flow model.

• Authors : Buntinx, Linde; Vermeersch, Steve; Hoon, Jan

Subjects: MIGRAINE; CAPSAICIN; PHARMACOKINETICS

• Source: British Journal of Clinical Pharmacology; Nov2015, Vol. 80 Issue 5, p992-1000, 9p, 2 Diagrams, 1 Chart, 2 Graphs

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