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Academic Journal

MEK1 is associated with carboplatin resistance and is a prognostic biomarker in epithelial ovarian cancer.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carboplatin/Carboplatin/Carboplatin/*pharmacology ; Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/*genetics

  • Source: BMC cancer [BMC Cancer] 2014 Nov 18; Vol. 14, pp. 837. Date of Electronic Publication: 2014 Nov 18.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Academic Journal

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.

  • Authors : Voisin L; Institut de Recherche en Immunologie et Cancérologie, Montreal, Quebec, Canada.; Julien C

Subjects: Cell Transformation, Neoplastic*; Adenocarcinoma/Adenocarcinoma/Adenocarcinoma/*secondary ; Intestinal Mucosa/Intestinal Mucosa/Intestinal Mucosa/*pathology

  • Source: BMC cancer [BMC Cancer] 2008 Nov 17; Vol. 8, pp. 337. Date of Electronic Publication: 2008 Nov 17.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression.

Subjects: NEUROBLASTOMA; TUMORS in children; MITOGEN-activated protein kinases

  • Source: BMC Cancer; 3/1/2016, Vol. 16, p1-10, 10p, 1 Diagram, 4 Graphs

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Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment.

  • Authors : Tosi D; Institut régional du Cancer de Montpellier (ICM), 208 avenue des Apothicaires, 34298, Montpellier, France. .; Pérez-Gracia E

Subjects: Drug Synergism*; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy ; Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/*genetics

  • Source: BMC cancer [BMC Cancer] 2018 Aug 13; Vol. 18 (1), pp. 812. Date of Electronic Publication: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Academic Journal

Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies.

  • Authors : Donnadieu J; Department of Head and Neck Surgery, University Hospital, Amiens, France.; Lachaier E

Subjects: Cell Culture Techniques* ; Molecular Targeted Therapy*; Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*drug therapy

  • Source: BMC cancer [BMC Cancer] 2016 Apr 16; Vol. 16, pp. 273. Date of Electronic Publication: 2016 Apr 16.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Academic Journal

Relapsing pneumonitis due to two distinct inhibitors of the MAPK/ERK pathway: report of a case.

  • Authors : Giraud V; AP-HP, Department of Pulmonary Medicine and Thoracic Oncology, Hôpital A. Paré, Boulogne, & université de Versailles SQY, Boulogne, France. .; Service de Pneumologie et d'Oncologie Thoracique, Hôpital Ambroise Paré, 9, avenue Charles de Gaulle, Boulogne, 92 104, France. .

Subjects: Indoles/Indoles/Indoles/*adverse effects ; MAP Kinase Signaling System/MAP Kinase Signaling System/MAP Kinase Signaling System/*drug effects ; Pneumonia/Pneumonia/Pneumonia/*chemically induced

  • Source: BMC cancer [BMC Cancer] 2015 Oct 19; Vol. 15, pp. 732. Date of Electronic Publication: 2015 Oct 19.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.

  • Authors : Pickhard AC; Department of Otolaryngology Head and Neck Surgery, Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany. ; Margraf J

Subjects: Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*pathology ; Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*radiotherapy ; Cell Movement/Cell Movement/Cell Movement/*drug effects

  • Source: BMC cancer [BMC Cancer] 2011 Sep 06; Vol. 11, pp. 388. Date of Electronic Publication: 2011 Sep 06.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.

  • Authors : O'Grady M; Invitrogen Corporation, Madison, WI 53719, USA. ; Raha D

Subjects: Gene Expression Regulation, Enzymologic* ; Gene Expression Regulation, Neoplastic* ; RNA Interference*

  • Source: BMC cancer [BMC Cancer] 2005 Oct 03; Vol. 5, pp. 125. Date of Electronic Publication: 2005 Oct 03.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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  • 1-8 of  8 results for ""MAP Kinase Kinase 1""