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Academic Journal

A potential mechanism for the cytoprotective effects of activated protein C-released endothelial extracellular vesicles.

  • Authors : Das K; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.; Keshava S

Subjects: Extracellular Vesicles*/Extracellular Vesicles*/Extracellular Vesicles*/metabolism ; Protein C*/Protein C*/Protein C*/metabolism ; Cytoprotection*

  • Source: Blood [Blood] 2024 Apr 18; Vol. 143 (16), pp. 1670-1675.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

Safety and efficacy of an anti-human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models.

  • Authors : Jiang M; Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, China.

Subjects: Protein C*/Protein C*/Protein C*/therapeutic use ; Hemophilia A*/Hemophilia A*/Hemophilia A*/drug therapy; Humans

  • Source: Blood [Blood] 2023 Sep 21; Vol. 142 (12), pp. 1071-1081.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

Activated protein C has a regulatory role in factor VIII function.

  • Authors : Wilhelm AR; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.; Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.

Subjects: Hemostasis*; Factor VIII/Factor VIII/Factor VIII/*metabolism ; Hemophilia A/Hemophilia A/Hemophilia A/*pathology

  • Source: Blood [Blood] 2021 May 06; Vol. 137 (18), pp. 2532-2543.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

The protein C activator AB002 rapidly interrupts thrombus development in baboons.

  • Authors : Tucker EI; Aronora, Inc, Portland, OR.; Department of Biomedical Engineering and.

Subjects: Fibrinolytic Agents/Fibrinolytic Agents/Fibrinolytic Agents/*pharmacology ; Protein C/Protein C/Protein C/*drug effects ; Thrombin/Thrombin/Thrombin/*analogs & derivatives

  • Source: Blood [Blood] 2020 Feb 27; Vol. 135 (9), pp. 689-699.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

Activated protein C, protease activated receptor 1, and neuroprotection.

  • Authors : Griffin JH; The Scripps Research Institute, La Jolla, CA.; Department of Medicine, University of California, San Diego, CA

Subjects: Neurons/Neurons/Neurons/*metabolism ; Protein C/Protein C/Protein C/*metabolism ; Receptor, PAR-1/Receptor, PAR-1/Receptor, PAR-1/*metabolism

  • Source: Blood [Blood] 2018 Jul 12; Vol. 132 (2), pp. 159-169. Date of Electronic Publication: 2018 Jun 04.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.

  • Authors : Sinha RK; The Scripps Research Institute, La Jolla, CA.; Wang Y

Subjects: Point Mutation* ; Proteolysis* ; Signal Transduction*

  • Source: Blood [Blood] 2018 Mar 15; Vol. 131 (11), pp. 1163-1171. Date of Electronic Publication: 2018 Jan 17.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells.

  • Authors : Sinha RK; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.; Flynn R

Subjects: Graft vs Host Disease/Graft vs Host Disease/Graft vs Host Disease/*drug therapy ; Protein C/Protein C/Protein C/*therapeutic use ; Receptor, PAR-1/Receptor, PAR-1/Receptor, PAR-1/*metabolism

  • Source: Blood [Blood] 2019 Aug 29; Vol. 134 (9), pp. 776-781. Date of Electronic Publication: 2019 Jun 26.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin.

  • Authors : Roy RV; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO.; Ardeshirylajimi A

Subjects: Signal Transduction*; Antigens, CD/Antigens, CD/Antigens, CD/*metabolism ; Protein C/Protein C/Protein C/*metabolism

  • Source: Blood [Blood] 2016 Oct 06; Vol. 128 (14), pp. 1884-1893. Date of Electronic Publication: 2016 Aug 25.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.

  • Authors : Gleeson EM; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, United Kingdom; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Crumlin, Dublin, United Kingdom

Subjects: Brain Ischemia/Brain Ischemia/Brain Ischemia/*metabolism ; Protein C/Protein C/Protein C/*metabolism ; Receptor, PAR-1/Receptor, PAR-1/Receptor, PAR-1/*metabolism

  • Source: Blood [Blood] 2015 Aug 13; Vol. 126 (7), pp. 915-9. Date of Electronic Publication: 2015 Jun 17.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays.

  • Authors : Ding Q; Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; and.

Subjects: Point Mutation*; Protein C/Protein C/Protein C/*genetics ; Protein C Deficiency/Protein C Deficiency/Protein C Deficiency/*diagnosis

  • Source: Blood [Blood] 2015 Apr 09; Vol. 125 (15), pp. 2428-34. Date of Electronic Publication: 2015 Feb 04.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  2,238 results for ""Protein C""