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Academic Journal

Potentialization of anticancer agents by identification of new chemosensitizers active under hypoxia.

  • Authors : Marx S; Department of Chemistry, NAmur MEdicine & Drug Innovation Center (NAMEDIC-NARILIS), University of Namur, 61 rue de Bruxelles, B-5000 Namur, Belgium.; Van Gysel M

Subjects: Drug Synergism*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*administration & dosage ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2019 Apr; Vol. 162, pp. 224-236. Date of Electronic Publication: 2019 Jan 07.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.

  • Authors : Heffeter P; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.; Pirker C

Subjects: Drug Resistance, Neoplasm*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Heterocyclic Compounds/Heterocyclic Compounds/Heterocyclic Compounds/*chemistry

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2012 Jun 15; Vol. 83 (12), pp. 1623-33. Date of Electronic Publication: 2012 Mar 15.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.

  • Authors : Yalowich JC; Division of Pharmacology, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA.; Wu X

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*antagonists & inhibitors ; Pyridines/Pyridines/Pyridines/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2012 Jul 01; Vol. 84 (1), pp. 52-8. Date of Electronic Publication: 2012 Apr 04.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.

  • Authors : Merlot AM; Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales 2006, Australia.; Shafie NH

Subjects: Gene Expression Regulation, Neoplastic*; Activating Transcription Factor 6/Activating Transcription Factor 6/Activating Transcription Factor 6/*genetics ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2016 Jun 01; Vol. 109, pp. 27-47. Date of Electronic Publication: 2016 Apr 06.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.

  • Authors : Cory JG; Department of Biochemistry, East Carolina University School of Medicine, Greenville, NC 27858.; Cory AH

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Pyridines/Pyridines/Pyridines/*pharmacology ; Ribonucleotide Reductases/Ribonucleotide Reductases/Ribonucleotide Reductases/*antagonists & inhibitors

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1994 Jul 19; Vol. 48 (2), pp. 335-44.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.

  • Authors : Sigmond J; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.; Kamphuis JA

Subjects: Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/*pharmacology ; Arabinofuranosylcytosine Triphosphate/Arabinofuranosylcytosine Triphosphate/Arabinofuranosylcytosine Triphosphate/*metabolism ; Cytarabine/Cytarabine/Cytarabine/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2007 May 15; Vol. 73 (10), pp. 1548-57. Date of Electronic Publication: 2007 Jan 21.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

  • Authors : Finch RA; Department of Pharmacology, Cancer Center, Yale University School of Medicine, New Haven, CT, USA.; Liu M

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Pyridines/Pyridines/Pyridines/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2000 Apr 15; Vol. 59 (8), pp. 983-91.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

Antitumor effects of bis-thiosemicarbazones--inhibition of deoxyribonucleic acid synthesis in vitro.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; DNA, Neoplasm/DNA, Neoplasm/DNA, Neoplasm/*antagonists & inhibitors ; Thiosemicarbazones/Thiosemicarbazones/Thiosemicarbazones/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1975 Jan 01; Vol. 24 (1), pp. 133-7.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

Mechanism of inhibition of ribonucleoside diphosphate reductase by a-(N)-heterocyclic aldehyde thiosemicarbazones.

Subjects: Nucleotidyltransferases/Nucleotidyltransferases/Nucleotidyltransferases/*metabolism ; Pyridines/Pyridines/Pyridines/*pharmacology ; Thiosemicarbazones/Thiosemicarbazones/Thiosemicarbazones/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1971 Nov; Vol. 20 (11), pp. 3119-23.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.

  • Authors : Ishiguro K; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, CT 06520, United States. Electronic address: .; Lin ZP

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Copper/Copper/Copper/*pharmacology ; Pyridines/Pyridines/Pyridines/*pharmacology

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2014 Oct 01; Vol. 91 (3), pp. 312-22. Date of Electronic Publication: 2014 Aug 15.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  41 results for ""THIOSEMICARBAZONES""