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Academic Journal

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling.

  • Authors : Holmes DA; Department of Immunology, Department of Translational Immunology, and Department of Pathology, Genentech, Inc., South San Francisco, CA 94080.; Suto E

Subjects: Lupus Erythematosus, Systemic/Lupus Erythematosus, Systemic/Lupus Erythematosus, Systemic/*enzymology ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/Protein Tyrosine Phosphatase, Non-Receptor Type 22/Protein Tyrosine Phosphatase, Non-Receptor Type 22/*metabolism ; Receptor, Interferon alpha-beta/Receptor, Interferon alpha-beta/Receptor, Interferon alpha-beta/*metabolism

  • Source: The Journal of experimental medicine [J Exp Med] 2015 Jun 29; Vol. 212 (7), pp. 1081-93. Date of Electronic Publication: 2015 Jun 15.Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium:

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Academic Journal

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

  • Authors : Zhang J; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Zahir N

Subjects: Lymphocyte Activation*; Autoimmune Diseases/Autoimmune Diseases/Autoimmune Diseases/*genetics ; Autoimmune Diseases/Autoimmune Diseases/Autoimmune Diseases/*immunology

  • Source: Nature genetics [Nat Genet] 2011 Aug 14; Vol. 43 (9), pp. 902-7. Date of Electronic Publication: 2011 Aug 14.Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

PTPN22 interacts with EB1 to regulate T-cell receptor signaling.

  • Authors : Zhang X; Institute of Biochemistry and Molecular Biology, College of Life and Health Sciences, Northeastern University, Shenyang, P.R. China.; Yu Y

Subjects: Protein Interaction Domains and Motifs*; Microtubule-Associated Proteins/Microtubule-Associated Proteins/Microtubule-Associated Proteins/*metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/Protein Tyrosine Phosphatase, Non-Receptor Type 22/Protein Tyrosine Phosphatase, Non-Receptor Type 22/*metabolism

  • Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jul; Vol. 34 (7), pp. 8959-8974. Date of Electronic Publication: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic

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Academic Journal

Association between PTPN22 C1858T polymorphism and juvenile idiopathic arthritis: A meta-analysis update with trial sequential analysis.

  • Authors : Lee YH; Department of Rheumatology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.; Song GG

Subjects: Arthritis, Juvenile*/Arthritis, Juvenile*/Arthritis, Juvenile*/genetics ; Genetic Predisposition to Disease* ; Polymorphism, Genetic*

  • Source: International journal of immunogenetics [Int J Immunogenet] 2022 Aug; Vol. 49 (4), pp. 271-278. Date of Electronic Publication: 2022 Jul 22.Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): Updated systematic review and meta-analysis.

  • Authors : Abbasifard M; Department of internal Medicine, Ali-Ibn Abi-Talib hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.; Rheumatology Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Subjects: Genetic Predisposition to Disease* ; Genome-Wide Association Study*; Arthritis, Rheumatoid/Arthritis, Rheumatoid/Arthritis, Rheumatoid/*genetics

  • Source: The journal of gene medicine [J Gene Med] 2020 Sep; Vol. 22 (9), pp. e3204. Date of Electronic Publication: 2020 Jun 03.Publisher: John Wiley & Sons Country of Publication: England NLM ID: 9815764 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.

  • Authors : Valta M; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Gazali AM

Subjects: Genotype*; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/Protein Tyrosine Phosphatase, Non-Receptor Type 22/Protein Tyrosine Phosphatase, Non-Receptor Type 22/*genetics

  • Source: European journal of immunology [Eur J Immunol] 2020 Apr; Vol. 50 (4), pp. 581-588. Date of Electronic Publication: 2019 Dec 19.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141

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Academic Journal

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene polymorphisms in liver transplant donors and impact on acute cellular liver transplant rejection.

  • Authors : Thude H; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Tiede P

Subjects: Graft Rejection*/Graft Rejection*/Graft Rejection*/genetics ; Liver Transplantation* ; Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/genetics

  • Source: HLA [HLA] 2020 Jan; Vol. 95 (1), pp. 40-44.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101675570 Publication Model: Print Cited Medium: Internet ISSN: 2059-2310

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Academic Journal

Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.

  • Authors : Spalinger MR; Department of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.; Division of Biomedical Sciences, University of California Riverside, Riverside, CA, USA.

Subjects: Fecal Microbiota Transplantation* ; Gastrointestinal Microbiome* ; Housing, Animal*

  • Source: Mucosal immunology [Mucosal Immunol] 2019 Nov; Vol. 12 (6), pp. 1336-1347. Date of Electronic Publication: 2019 Sep 09.Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.

  • Authors : Jabeen A; Department of Zoology, Government College University, Lahore, 54000, Pakistan.; Riaz S

Subjects: Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/genetics ; Intercellular Adhesion Molecule-1*/Intercellular Adhesion Molecule-1*/Intercellular Adhesion Molecule-1*/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/genetics

  • Source: Molecular biology reports [Mol Biol Rep] 2024 Oct 19; Vol. 51 (1), pp. 1070. Date of Electronic Publication: 2024 Oct 19.Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978

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Academic Journal

PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease.

  • Authors : Cai H; Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China. Electronic address: .; Chen S

Subjects: Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/Protein Tyrosine Phosphatase, Non-Receptor Type 22*/metabolism ; Graves Disease*/Graves Disease*/Graves Disease*/pathology

  • Source: Tissue & cell [Tissue Cell] 2024 Oct; Vol. 90, pp. 102502. Date of Electronic Publication: 2024 Jul 27.Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  10,967 results for ""PEP""