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Academic Journal

Soluble guanylyl cyclase stimulators and activators: Promising drugs for the treatment of hypertension?

  • Authors : Gawrys O; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. Electronic address: .; Kala P

Subjects: Hypertension*/Hypertension*/Hypertension*/drug therapy ; Hypertension*/Hypertension*/Hypertension*/physiopathology ; Soluble Guanylyl Cyclase*/Soluble Guanylyl Cyclase*/Soluble Guanylyl Cyclase*/metabolism

  • Source: European journal of pharmacology [Eur J Pharmacol] 2025 Jan 15; Vol. 987, pp. 177175. Date of Electronic Publication: 2024 Dec 05.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

GefB, a GGDEF domain-containing protein, affects motility and biofilm formation of Vibrio parahaemolyticus and is regulated by quorum sensing regulators.

  • Authors : Zhou Y; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, China; Department of Clinical Laboratory, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong 226006, Jiangsu, China.

Subjects: Vibrio parahaemolyticus*/Vibrio parahaemolyticus*/Vibrio parahaemolyticus*/genetics ; Vibrio parahaemolyticus*/Vibrio parahaemolyticus*/Vibrio parahaemolyticus*/metabolism ; Biofilms*/Biofilms*/Biofilms*/growth & development

  • Source: Gene [Gene] 2025 Jan 15; Vol. 933, pp. 148968. Date of Electronic Publication: 2024 Sep 26.Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Alanine mutation of the targeting subunit of the myosin phosphatase, MYPT1 at threonine 696 reduces cGMP responsiveness of mouse femoral arteries.

  • Authors : Lubomirov LT; Institute of Physiology, Brandenburg Medical School Theodor Fontane, Germany; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany

Subjects: Femoral Artery*/Femoral Artery*/Femoral Artery*/drug effects ; Femoral Artery*/Femoral Artery*/Femoral Artery*/metabolism ; Myosin-Light-Chain Phosphatase*/Myosin-Light-Chain Phosphatase*/Myosin-Light-Chain Phosphatase*/metabolism

  • Source: European journal of pharmacology [Eur J Pharmacol] 2025 Jan 05; Vol. 986, pp. 177133. Date of Electronic Publication: 2024 Nov 17.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Choline metabolism modulates cyclic-di-GMP signaling and virulence of Pseudomonas aeruginosa in a macrophage infection model.

  • Authors : Zhou Y; Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.; Department of Laboratory Medicine, Shenzhen University General Hospital, Shenzhen, 518000, China.

Subjects: Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/pathogenicity ; Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/metabolism ; Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/genetics

  • Source: BMC infectious diseases [BMC Infect Dis] 2024 Dec 27; Vol. 24 (1), pp. 1466. Date of Electronic Publication: 2024 Dec 27.Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334

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Academic Journal

Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET.

  • Authors : Eggan P; Department of Physiology and Biophysics, University of Washington, Seattle, United States.; Gordon SE

Subjects: Fluorescence Resonance Energy Transfer*/Fluorescence Resonance Energy Transfer*/Fluorescence Resonance Energy Transfer*/methods ; Protein Conformation* ; Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism

  • Source: ELife [Elife] 2024 Dec 10; Vol. 13. Date of Electronic Publication: 2024 Dec 10.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

Vibrio parahaemolyticus Down-Regulates the Intracellular c-di-GMP Level to Promote Swarming Motility by Sensing Surface.

  • Authors : Ge Q; College of Animal Science and Technology, College of Veterinary Medicine, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Zhejiang A & F University, Hangzhou, China.; Gao M

Subjects: Cyclic GMP*/Cyclic GMP*/Cyclic GMP*/analogs & derivatives ; Cyclic GMP*/Cyclic GMP*/Cyclic GMP*/metabolism ; Vibrio parahaemolyticus*/Vibrio parahaemolyticus*/Vibrio parahaemolyticus*/genetics

  • Source: Current microbiology [Curr Microbiol] 2024 Dec 09; Vol. 82 (1), pp. 32. Date of Electronic Publication: 2024 Dec 09.Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Regulation and Pharmacology of the Cyclic GMP and Nitric Oxide Pathway in Embryonic and Adult Stem Cells.

  • Authors : Kots AY; Veteran Affairs Palo Alto Health Care System, US Department of Veteran Affairs, Palo Alto, CA 90304, USA.; Bian K

Subjects: Adult Stem Cells*/Adult Stem Cells*/Adult Stem Cells*/cytology ; Adult Stem Cells*/Adult Stem Cells*/Adult Stem Cells*/drug effects ; Adult Stem Cells*/Adult Stem Cells*/Adult Stem Cells*/metabolism

  • Source: Cells [Cells] 2024 Dec 05; Vol. 13 (23). Date of Electronic Publication: 2024 Dec 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload.

  • Authors : Fukuma N; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8655, Japan.; Division of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Subjects: Estrogen Receptor alpha*/Estrogen Receptor alpha*/Estrogen Receptor alpha*/metabolism ; Estrogen Receptor alpha*/Estrogen Receptor alpha*/Estrogen Receptor alpha*/genetics ; Estrogen Receptor alpha*/Estrogen Receptor alpha*/Estrogen Receptor alpha*/deficiency

  • Source: Cardiovascular research [Cardiovasc Res] 2024 Dec 04; Vol. 120 (15), pp. 1884-1897.Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245

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Academic Journal

Renal Effects of Combination Phosphodiesterase V Inhibition and Low-Dose B-Type Natriuretic Peptide in Acute Heart Failure: A Randomized Clinical Trial.

  • Authors : Hubers SA; Department of Cardiovascular Medicine (S.A.H., P.M.M.K., H.H.C.), Mayo Clinic, Rochester, MN.; Minneapolis Heart Institute, United Hospital, St. Paul (S.A.H.).

Subjects: Natriuretic Peptide, Brain*/Natriuretic Peptide, Brain*/Natriuretic Peptide, Brain*/blood ; Heart Failure*/Heart Failure*/Heart Failure*/drug therapy ; Heart Failure*/Heart Failure*/Heart Failure*/physiopathology

  • Source: Circulation. Heart failure [Circ Heart Fail] 2024 Dec; Vol. 17 (12), pp. e011761. Date of Electronic Publication: 2024 Nov 08.Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101479941 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Deletion of AT 1a receptors selectively in the proximal tubules of the kidney alters the hypotensive and natriuretic response to atrial natriuretic peptide via NPR A /cGMP/NO signaling.

  • Authors : Li XC; Tulane Hypertension and Renal Center of Excellence and Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, United States.; Wang CH

Subjects: Kidney Tubules, Proximal*/Kidney Tubules, Proximal*/Kidney Tubules, Proximal*/metabolism ; Kidney Tubules, Proximal*/Kidney Tubules, Proximal*/Kidney Tubules, Proximal*/drug effects ; Cyclic GMP*/Cyclic GMP*/Cyclic GMP*/metabolism

  • Source: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2024 Dec 01; Vol. 327 (6), pp. F946-F956. Date of Electronic Publication: 2024 Oct 03.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  9,695 results for ""CYCLIC guanylic acid""