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Academic Journal

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes.

  • Authors : Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore.; Ghosh S

Subjects: Hepatocyte Nuclear Factor 4*/Hepatocyte Nuclear Factor 4*/Hepatocyte Nuclear Factor 4*/metabolism ; Hepatocyte Nuclear Factor 4*/Hepatocyte Nuclear Factor 4*/Hepatocyte Nuclear Factor 4*/genetics ; Hepatocyte Nuclear Factor 1-alpha*/Hepatocyte Nuclear Factor 1-alpha*/Hepatocyte Nuclear Factor 1-alpha*/metabolism Mason-Type Diabetes

  • Source: Nature communications [Nat Commun] 2024 Jun 22; Vol. 15 (1), pp. 4288. Date of Electronic Publication: 2024 Jun 22.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer.

  • Authors : Bai H; Westlake Disease Modeling lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.

Subjects: Cellular Senescence* ; Aging* ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology

  • Source: Nature communications [Nat Commun] 2024 Jun 17; Vol. 15 (1), pp. 5154. Date of Electronic Publication: 2024 Jun 17.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis.

  • Authors : Wang H; Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.; Du Y

Subjects: Single-Cell Analysis*/Single-Cell Analysis*/Single-Cell Analysis*/methods ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/metabolism ; Homeostasis*

  • Source: Nature communications [Nat Commun] 2024 Jun 06; Vol. 15 (1), pp. 4827. Date of Electronic Publication: 2024 Jun 06.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD.

Subjects: Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/blood ; Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/diagnosis ; Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/pathology

  • Source: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4564. Date of Electronic Publication: 2024 May 29.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism.

  • Authors : Wahlström A; Wallenberg Laboratory and Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Brumbaugh A

Subjects: Deoxycholic Acid*/Deoxycholic Acid*/Deoxycholic Acid*/metabolism ; Gastrointestinal Microbiome*/Gastrointestinal Microbiome*/Gastrointestinal Microbiome*/physiology ; Glucose*/Glucose*/Glucose*/metabolism

  • Source: Nature communications [Nat Commun] 2024 May 20; Vol. 15 (1), pp. 4276. Date of Electronic Publication: 2024 May 20.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts.

  • Authors : Westhoff M; Department of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.; Del Villar SG

Subjects: Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/metabolism ; Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/genetics ; Aging*/Aging*/Aging*/metabolism

  • Source: Nature communications [Nat Commun] 2024 Apr 25; Vol. 15 (1), pp. 3528. Date of Electronic Publication: 2024 Apr 25.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

An estrogen receptor α-derived peptide improves glucose homeostasis during obesity.

  • Authors : Yang W; Department of Nutrition, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX, 77843, USA.; Jiang W

Subjects: Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/drug therapy ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/metabolism ; Estrogen Receptor alpha*/Estrogen Receptor alpha*/Estrogen Receptor alpha*/metabolism

  • Source: Nature communications [Nat Commun] 2024 Apr 22; Vol. 15 (1), pp. 3410. Date of Electronic Publication: 2024 Apr 22.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Trimethylamine N-oxide impairs β-cell function and glucose tolerance.

  • Authors : Kong L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing, China.

Subjects: Diabetes Mellitus, Type 2*; Humans ; Male

  • Source: Nature communications [Nat Commun] 2024 Mar 21; Vol. 15 (1), pp. 2526. Date of Electronic Publication: 2024 Mar 21.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling.

  • Authors : Wang X; Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, 710068, China.; Zhu L

Subjects: Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/metabolism ; Plaque, Atherosclerotic*/Plaque, Atherosclerotic*/Plaque, Atherosclerotic*/metabolism; Animals

  • Source: Nature communications [Nat Commun] 2024 Feb 12; Vol. 15 (1), pp. 1281. Date of Electronic Publication: 2024 Feb 12.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Detection of senescence using machine learning algorithms based on nuclear features.

  • Authors : Duran I; MRC Laboratory of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.

Subjects: Aging*/Aging*/Aging*/physiology ; Cellular Senescence*/Cellular Senescence*/Cellular Senescence*/physiology; Animals

  • Source: Nature communications [Nat Commun] 2024 Feb 03; Vol. 15 (1), pp. 1041. Date of Electronic Publication: 2024 Feb 03.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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