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Academic Journal

Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents.

Authors : Yujin Guo; Beibei Chen; Jinxiu Guo

Subjects: BIOSYNTHESIS; ANTINEOPLASTIC agents; PODOPHYLLOTOXIN

Source: Pharmaceutical Biology. Dec2024, Vol. 62 Issue 1, p233-240. 17p.

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Academic Journal

Conformation and energy investigation of microtubule longitudinal dynamic instability induced by natural products.

Authors : Chu, Yanyan (AUTHOR); Tian, Zhenhua (AUTHOR); Yang, Mengke (AUTHOR)

Subjects: TUBULINS; MICROTUBULES; NATURAL products

Source: Chemical Biology & Drug Design. Sep2023, Vol. 102 Issue 3, p444-456. 13p.

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Academic Journal

Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity.

Authors : Jiménez, Verónica A.; Alderete, Joel B.; Navarrete, Karen R.

Subjects: MOLECULAR dynamics; TUBULIN structure; MICROTUBULES

Source: Chemical Biology & Drug Design. Dec2017, Vol. 90 Issue 6, p1247-1259. 13p.

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Academic Journal

Design, synthesis, and biological evaluation of 2,3‐diphenyl‐cycloalkyl pyrazole derivatives as potential tubulin polymerization inhibitors.

Authors : Xia, Lin‐Ying (AUTHOR); Yang, Rong (AUTHOR); Zhang, Ya‐Liang (AUTHOR)

Subjects: PYRAZOLE derivatives; CELL cycle; POLYMERIZATION

Source: Chemical Biology & Drug Design. Nov2019, Vol. 94 Issue 5, p1894-1904. 11p.

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Academic Journal

Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.

Authors : Komuraiah, Buduma (AUTHOR); Ren, Yichang (AUTHOR); Xue, Mingming (AUTHOR)

Subjects: BIOSYNTHESIS; HETEROCYCLIC compounds; TUBULINS

Source: Chemical Biology & Drug Design. May2021, Vol. 97 Issue 5, p1109-1116. 8p.

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Academic Journal

Systematic profiling of Taxol resistance and sensitivity to tubulin missence mutations at molecular and cellular levels.

Authors : Zhou, Lihua (AUTHOR); Ding, Xi (AUTHOR); Cao, Jingjing (AUTHOR)

Subjects: TUBULINS; PACLITAXEL; GENETIC mutation

Source: Chemical Biology & Drug Design. Apr2024, Vol. 103 Issue 4, p1-9. 9p.

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Discovery of Small Molecule Inhibitors that Interact with γ-Tubulin.

Authors : Friesen, Douglas E.; Barakat, Khaled H.; Semenchenko, Valentyna

Subjects: TUBULINS; MOLECULAR dynamics; GLIOBLASTOMA multiforme

Source: Chemical Biology & Drug Design. May2012, Vol. 79 Issue 5, p639-652. 14p. 5 Color Photographs, 5 Diagrams, 2 Charts, 2 Graphs.

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Academic Journal

Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway.

Authors : Qi, Jianguo; Huang, Jing; Zhou, Xiaomin

Subjects: CHEMICAL synthesis; QUINOXALINES; POLYMERIZATION

Source: Chemical Biology & Drug Design. Apr2019, Vol. 93 Issue 4, p617-627. 11p.

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Academic Journal

Experimental and Computational Study of the Interaction of Novel Colchicinoids with a Recombinant Human α I/β I-Tubulin Heterodimer.

Authors : Mane, Jonathan Y.; Semenchenko, Valentyna; Perez ‐ Pineiro, Rolando

Subjects: TUBULINS; COLCHICINE; CHEMICALS

Source: Chemical Biology & Drug Design. Jul2013, Vol. 82 Issue 1, p60-70. 11p. 3 Charts, 3 Graphs.

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Academic Journal

HDAC8 drives spindle organization during meiotic maturation of porcine oocytes.

Authors : Chen, Ying (AUTHOR); Pan, Chen (AUTHOR); Lu, Yajuan (AUTHOR)

Subjects: SPINDLE apparatus; CHROMOSOME structure; HISTONE deacetylase

Source: Cell Proliferation. Oct2021, Vol. 54 Issue 10, p1-10. 10p.

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Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents.

Conformation and energy investigation of microtubule longitudinal dynamic instability induced by natural products.

Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity.

Design, synthesis, and biological evaluation of 2,3‐diphenyl‐cycloalkyl pyrazole derivatives as potential tubulin polymerization inhibitors.

Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.

Systematic profiling of Taxol resistance and sensitivity to tubulin missence mutations at molecular and cellular levels.

Discovery of Small Molecule Inhibitors that Interact with γ-Tubulin.

Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway.

Experimental and Computational Study of the Interaction of Novel Colchicinoids with a Recombinant Human α I/β I-Tubulin Heterodimer.

HDAC8 drives spindle organization during meiotic maturation of porcine oocytes.

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