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Academic Journal

Aquaporin Channels in Skin Physiology and Aging Pathophysiology: Investigating Their Role in Skin Function and the Hallmarks of Aging This study examines the critical role of aquaporins (AQPs) in skin physiology and aging pathophysiology. The skin plays a vital role in maintaining homeostasis by acting as a protective barrier against external pathogens and excessive water loss, while also contributing to the appearance and self-esteem of individuals. Key physiological features, such as elasticity and repair capability, are essential for its proper function. However, with aging, these characteristics deteriorate, reducing the skin's ability to tolerate environmental stressors which contribute to external aging as well as internal aging processes, which negatively affect barrier function, immune response, and overall well-being. AQPs, primarily known for facilitating water transport, are significant for normal skin functions, including hydration and the movement of molecules like glycerol and hydrogen peroxide, which influence various cellular processes and functions. In this context, we categorized aquaporin dysfunction into several hallmarks of aging, including mitochondrial dysfunction, cellular senescence, stem cell depletion, impaired macroautophagy, dysbiosis, and inflamm-aging. Eight aquaporins (AQP1, 3, 5, 7, 8, 9, 10, and 11) are expressed in various skin cells, regulating essential processes such as cell migration, proliferation, differentiation, and also immune response. Dysregulation or altered expression of these proteins can enhance skin aging and related pathologies by activating these hallmarks. This study provides valuable insights into the potential of targeting aquaporins to mitigate skin aging and improve skin physiologic functions.

Subjects: SKIN physiology; CELLULAR aging; AQUAPORINS

  • Source: Biology (2079-7737); Nov2024, Vol. 13 Issue 11, p862, 20p

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Academic Journal

Aquaporins in sepsis- an update.

Subjects: AQUAPORINS; PULMONARY gas exchange; ADULT respiratory distress syndrome

  • Source: Frontiers in Immunology; 2024, p1-14, 14p

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Academic Journal

Expression patterns of maize PIP aquaporins in middle or upper leaves correlate with their different physiological responses to drought and mycorrhiza.

Subjects: CELL membranes; PHOTOSYNTHETIC rates; AQUAPORINS

  • Source: Frontiers in Plant Science; 2024, p1-14, 14p

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A Step Forward in Understanding the Expression of Classical Aquaporins in the Male Reproductive Tract: Study Findings in Cattle (Bos taurus).

Subjects: CATTLE; VAS deferens; AQUAPORINS

  • Source: International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 14, p7653, 14p

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Academic Journal

Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins.

Subjects: MEMBRANE proteins; CELL membranes; MOLECULAR dynamics

  • Source: Biochemical Journal; Oct2024, Vol. 481 Issue 19, p1329-1347, 19p

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Academic Journal

Plant aquaporins: Their roles beyond water transport.

Subjects: AQUAPORINS; PLANT growth; PLANT development

  • Source: Crop Journal (2095-5421); Jun2024, Vol. 12 Issue 3, p641-655, 15p

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Academic Journal

Differential root and cell regulation of maize aquaporins by the arbuscular mycorrhizal symbiosis highlights its role in plant water relations.

Subjects: GENETIC regulation; GENE expression; WATER supply

  • Source: Plant, Cell & Environment; Nov2024, Vol. 47 Issue 11, p4337-4353, 17p

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Aquaporins: Multifunctional Players in Plant Growth, Development and Stress Responses.

Subjects: AQUAPORINS; PLANT growth; BIOLOGICAL membranes

  • Source: Silva Balcanica; 2024, Vol. 25 Issue 1, p73-86, 14p

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Characterization of SIPs-type aquaporins and their roles in response to environmental cues in rice (Oryza sativa L.).

Subjects: AQUAPORINS; BASIC proteins; BIOLOGICAL membranes

  • Source: BMC Plant Biology; 4/22/2024, Vol. 24 Issue 1, p1-15, 15p

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Academic Journal

Multifaceted role and regulation of aquaporins for efficient stomatal movements.

Subjects: GAS exchange in plants; WATER efficiency; AQUAPORINS

  • Source: Plant, Cell & Environment; Sep2024, Vol. 47 Issue 9, p3330-3343, 14p

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  • 1-10 of  24,910 results for ""Aquaporins""