The Baeyer-Villiger Oxidation with Trifluoroacetic Acid and Household Sodium Percarbonate

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  • Additional Information
    • Availability:
      Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: [email protected]; Web site: http://www.jce.divched.org
    • Peer Reviewed:
      Y
    • Source:
      2
    • Education Level:
      Higher Education
    • Subject Terms:
      Organic Chemistry; Hands on Science; Experiential Learning; Science Instruction; Undergraduate Students; College Science; Laboratory Experiments
    • ISSN:
      0021-9584
    • Abstract:
      A method for carrying out the Baeyer-Villiger oxidation of cyclopentanone to [delta]-valerolactone in a large-section introductory organic chemistry laboratory course is reported. The oxidizing agent is trifluoroperoxyacetic acid generated in situ from trifluoroacetic acid and household sodium percarbonate such as OxiClean, Oxi Magic, or Oxy-Boost. A class of 27 students can easily carry out the reaction and record a [to the first power]H NMR spectrum within a 3-hour lab period. Students typically report a 50% yield of isolated material. (Contains 1 table.)
    • Abstract:
      As Provided
    • Number of References:
      12
    • Publication Date:
      2009
    • Accession Number:
      EJ827391