A Knoevenagel Initiated Annulation Reaction Using Room Temperature or Microwave Conditions

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  • Additional Information
    • Availability:
      Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: [email protected]; Web site: http://www.jce.divched.org
    • Peer Reviewed:
      Y
    • Source:
      3
    • Education Level:
      Higher Education
    • Subject Terms:
      Chemistry; Climate; Laboratory Experiments; Molecular Structure; Textbooks; Inorganic Chemistry; College Science
    • ISSN:
      0021-9584
    • Abstract:
      An experiment is presented that has the student execute a Knoevenagel initiated annulation reaction. The reaction can be carried out either through use of a microwave reactor or by allowing the mixture to stand at room temperature for two days. The student is then challenged to identify the reaction product through a guided prelab exercise of the synthesis of the Hagemann ester, and then through GC-MS, NMR, and IR spectra of the product. The stereochemistry of the product is determined through the NMR spectrum and the Karplus curve. The student is required to write a mechanism for the reaction. (Contains 2 figures.)
    • Abstract:
      As Provided
    • Number of References:
      20
    • Publication Date:
      2008
    • Accession Number:
      EJ820775