Examining Associations between Prenatal Biomarkers of Oxidative Stress and ASD-Related Outcomes Using Quantile Regression

Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: [email protected]; Web site: https://link.springer.com/

Y

11

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (DHHS/NIH)

R21HD096356

Physiology; Prenatal Influences; Autism Spectrum Disorders; Pregnancy; Siblings; Biochemistry; Interpersonal Competence; Correlation; Children

10.1007/s10803-022-05625-9

0162-3257
1573-3432

We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile [beta]: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

As Provided

2023

EJ1382998